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Zastrupitev z etilenglikolom
Nina Hojs, Robert Ekart, Franc Svenšek, 2011, professional article

Abstract: Zastrupitve z etilenglikolom so dokaj redke. Etilenglikol je sam po sebi malo toksičen, hudo zastrupitev povzročajo predvsem njegovi presnovni produkti. Prikazani primer obravnava značilno klinično sliko (nevrološka, kardiopulmonalna in ledvična faza) in laboratorijske rezultate (povišana serumska osmolalnost, povišana osmolalna vrzel, metabolična acidoza s povišano anionsko vrzeljo, kristali kalcijevega oksalata v urinu) ob zastrupitvi z etilenglikolom. Hitra prepoznava je nujna, saj sta obolevnost in smrtnost po zastrupitvi visoki. Zdravljenje vključuje vzdrževanje dihalne poti, dihanja in krvnega obtoka, infuzijo bikarbonata, dajanje antidota (etanol, fomepizol), hemodializo, včasih tudi zdravljenje s kofaktorji presnove etilenglikola (tiamin, piridoksin, magnezij).
Keywords: Acid-Base Equilibrium, Acido-bazno ravnotežje, diagnosis, Diagnostika, Emergency Treatment, Ethylene Glycol, Etilenglikol, klinična slika, Nujno ukrepanje, Osmolar Concentration, Osmolarna koncentracija, poisoning, therapy, Zastrupitve, Zdravljenje
Published: 30.12.2015; Views: 1277; Downloads: 59
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3.
Induction gemcitabine in standard dose or prolonged low-dose with cisplatin followed by concurrent radiochemotherapy in locally advanced non-small cell lung cancer
Martina Vrankar, Matjaž Zwitter, Tanja Bavčar-Vodovnik, Ana Milič, Viljem Kovač, 2014, original scientific article

Abstract: Background: The optimal combination of chemotherapy with radiation therapy for treatment locally advanced non-small cell lung cancer (NSCLC) remains an open issue. This randomized phase II study compared gemcitabine in two different schedules and cisplatin - as induction chemotherapy, followed by radiation therapy concurrent with cisplatin and etoposid. Patients and methods: Eligible patients had microscopically confirmed inoperable non-metastatic non-small cell lung cancer; fulfilled the standard criteria for platin-based chemotherapy; and signed informed consent. Patients were treated with 3 cycles of induction chemotherapy with gemcitabine and cisplatin. Two different aplications of gemcitabine were compared: patients in arm A received gemcitabine at 1250 mg/m2 in a standard half hour i.v. infusion on days 1 and 8; patients in arm B received gemcitabine at 250 mg/m2 in prolonged 6-hours i.v. infusion on days 1 and 8. In both arms, cisplatin 75 mg/m2 on day 2 was administered. All patients continued treatment with radiation therapy with 60-66 Gy concurrent with cisplatin 50 mg/m2 on days 1, 8, 29 and 36 and etoposid 50 mg/m2 on days 1-5 and 29-33. The primary endpoint was response rate (RR) after induction chemotherapy; secondary endpoints were toxicity, progression-free survival (PFS) and overall survival (OS). Results: From September 2005 to November 2010, 106 patients were recruited to this study. No statistically signifficant differences were found in RR after induction chemotherapy between the two arms (48.1% and 57.4%, p = 0.34). Toxicity profile was comparable and mild with grade 3/4 neutropenia as primary toxicity in both arms. One patient in arm B suffered from acute peripheral ischemia grade 4 and an amputation of lower limb was needed. With a median follow-up of 69.3 months, progression-free survival and median survival in arm A were 15.7 and 24.8 months compared to 18.9 and 28.6 months in arm B. The figures for 1- and 3-year overall survival were 73.1% and 30.8% in arm A, and 81.5 % and 44.4% in arm B, respectively. Conclusions: Among the two cisplatin-based doublets of induction chemotherapy for inoperable NSCLC, both schedules of gemcitabine have a comparable toxicity profile. Figures for RR, PFS and OS are among the best reported in current literature. While there is a trend towards better efficacy of the treament with prolonged infusion of gemcitabine, the difference between the two arms did not reach statistical significance.
Keywords: induction chemotherapy, non-small cell lung cancer, radiation therapy, randomized clinical trial
Published: 05.04.2017; Views: 404; Downloads: 38
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4.
Prognostic factors of choroidal melanoma in Slovenia, 1986-2008
Boris Jančar, Marjan Budihna, Brigita Drnovšek-Olup, Katrina Novak-Andrejčič, Irena-Hedvika Brovet-Zupančič, Dušica Pahor, 2016, original scientific article

Abstract: Introduction: Choroidal melanoma is the most common primary malignancy of the eye, which frequently metastasizes. The Cancer Registry of Slovenia reported the incidence of choroid melanoma from 1983 to 2009 as stable, at 7.8 cases/million for men and 7.4/million for women. The aim of the retrospective study was to determinate the prognostic factors of survival for choroidal melanoma patients in Slovenia. Patients and methods: From January 1986 to December 2008 we treated 288 patients with malignant choroidal melanoma; 127 patients were treated by brachytherapy with beta rays emitting ruthenium-106 applicators; 161 patients were treated by enucleation. Results: Patients with tumours thickness < 7.2 mm and base diameter < 16 mm were treated by brachytherapy and had 5- and 10-year overall mortality 13% and 32%, respectively. In enucleated patients, 5- and 10-year mortality was higher, 46% and 69%, respectively, because their tumours were larger. Thirty patients treated by brachytherapy developed local recurrence. Twenty five of 127 patients treated by brachytherapy and 86 of 161 enucleated patients developed distant metastases. Patients of age >/= 60 years had significantly lower survival in both treatment modalities. For patients treated by brachytherapy the diameter of the tumour base and treatment time were independent prognostic factors for overall survival, for patients treated by enucleation age and histological type of tumour were independent prognosticators. In first few years after either of treatments, the melanoma specific annual mortality rate increased, especially in older patients, and then slowly decreased. Conclusions: It seems that particularly younger patients with early tumours can be cured, whereby preference should be given to eyesight preserving brachytherapy over enucleation.
Keywords: choroidal melanoma, therapy, brachytherapy, prognostic factors
Published: 05.04.2017; Views: 257; Downloads: 135
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5.
Disability in patients with chronic non-specific low back pain
Zalika Klemenc-Ketiš, 2011, original scientific article

Abstract: Aim: To validate the Slovene version of the Oswestry Disability Index. Method: A case series study of 129 adult patients with non-specific chronic low back pain attending a 10-day physical therapy programme. Visual Analog Pain Scale (VAS), Euroqol questionnaire (EQq), and Oswestry Disability Index (ODI) were used at the beginning and at the end of the physical therapy programme. Results: Cronbach's a of the Slovene ODI was 0.876 at the beginning of the physical therapy programme and 0.901 at the end of the programme. All items of the questionnaire loaded on the same factor. A significant positive correlation existed between the Slovene ODI and VAS, EQ-5D and EQ-VAS at the beginning of the physical therapy programme (r=0.630, p<0.001; r=0.657, p<0.001; r=-0.510, p<0.001, respectively), as well as at the end of the programme (r=0.491, p<0.001; r=0.725, p<0.001; r=-0.648, p<0.001, respectively). The difference between ODI scores obtained at the first and at the second interview was 2.7 ± 5.2 (p<0.001), and the difference between ODI disability scores was 5.4 ± 10.5 (p<0.001). The effect size of the Slovene ODI questionnaire was 0.30. Conclusions: The Slovene ODI questionnaire is a reliable and valid instrument for assessing outcomes of physical therapy in patients with chronic non-specific low back pain.
Keywords: disability evaluation, low back pain, physical therapy, validation studies, questionnaire
Published: 05.04.2017; Views: 741; Downloads: 118
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6.
High-school Students' Use of Fantasy and Science Fiction Reading for Escapism
Janja Papac, 2017, master's thesis

Abstract: The thesis “High-school Students’ Use of Fantasy and Science Fiction Reading for Escapism” encompasses findings connected to adolescence and young adult literature. We present the emotional, cognitive and social characteristics of adolescence. We take a look at the influence that childhood traumas and defense mechanisms may have on adolescents. We also present findings connected to escapism and reading therapy. The genres from the title – fantasy and science fiction - are described, as well as their history. We also described fairytales and folktales. We took a closer look at the Harry Potter book series and the opinion some critics have about its influence on youth, as well as some well-known fairytales children can identify with. In the empirical part, we presented the results of a survey created to examine the reading habits and motivation of high-school students. We found that high-school students’ general satisfaction with life does not greatly influence their choice of reading materials.
Keywords: high-school students, adolescence, literature, fantasy, science fiction, fairytales, escapism, reading therapy
Published: 13.10.2017; Views: 348; Downloads: 65
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7.
Teachers' views of the potential of art therapy in young learners
Ivana Marijanović, Dubravka Kuščević, Ina Reić-Ercegovac, 2017, original scientific article

Abstract: The aim of the study conducted on 205 class teachers was to explore the extent to which they care about their pupil's artistic expression, how much they know about art therapy and it's potential for young learners, especially when working with abused children and children with developmental disabilities, and their willingness to seek additional knowledge about art therapy. The research results showed no significant difference in art therapy knowledge and its implementation when working with young children according to teachers' age, work experience or education. Still, the assessment of their own knowledge about art therapy and its potential did differ according to age and level of education.
Keywords: art therapy, class teacher, elementary teacher education, art education, fine arts
Published: 23.04.2018; Views: 244; Downloads: 165
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