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1.
Supercritical fluid chromatography and scale up study
Miha Oman, Petra Kotnik, Mojca Škerget, Željko Knez, 2014, original scientific article

Abstract: The influence of process parameters on supercritical fluid chromatography (SFC) and scale-up on to the preparative scale was investigated. In this scope, dependency of pressure, temperature, type and concentration of modifier, and type of stationary phase on the separation were examined separately. Experiments were performed on silica stationary phases in the range of pressures from 100 bar to 250 bar and temperatures from 30°C to 65°C, with use of ethanol and methanol as modifier. Results obtained on analytical scale were used for scale up on preparative (to production) scale. The aim of this study is presentation of the state-of-the-art of SFC through separate effects of process parameters on the separation and investigation of development, benefits and drawbacks of scaling-up process of the SFC.
Keywords: supercritical fluids, supercritical fluid chromatograpy, chromatography, scale up study, SFC
Published: 21.12.2015; Views: 836; Downloads: 77
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2.
Supercritical fluid adsorption and desorption of lipids on various adsorbents
Mojca Škerget, Željko Knez, 2007, original scientific article

Abstract: In present work the feasibility of using supercritical fluid chromatography (SFC) for separation of free fatty acids (FFA) and triglycerides has been examined. Lipids such as oleic acid and sunflower oil (containing 96% of triglycerides) were used; adsorption and desorption on adsorbents such as silica gel and neusilin using supercritical $CO_2$ as mobile phase was investigated. The experiments were performed at 40 °C and in the pressure range from 13 to 30 MPa. Adsorption kinetic lines were determined by analysingbreakthrough curves. Several parameters such as rate of adsorption and desorption, loading, desorbed quantity and diffusion coefficients in solid phase were calculated.
Keywords: supercritical fluid chromatography, lipids, oleic acid, triglycerides, adsorption, desorption
Published: 31.05.2012; Views: 1710; Downloads: 69
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