| | SLO | ENG | Cookies and privacy

Bigger font | Smaller font

Search the digital library catalog Help

Query: search in
search in
search in
search in
* old and bologna study programme

Options:
  Reset


1 - 1 / 1
First pagePrevious page1Next pageLast page
1.
Synthesis and use of organic biodegradable aerogels as drug carriers
Anja Veronovski, Zoran Novak, Željko Knez, 2012, original scientific article

Abstract: Aerogels of natural polysaccharides possess both biocharacteristics of polysaccharides, such as good biological compatibility and cell or enzyme-controlled degradability, and aerogel characteristics, such as very high porosity and specific surface areas that makes them highly attractive in drug delivery. Biodegradable alginate aerogels were synthesized via a sol-gel process. In the present work two methods of ionic cross-linking were used to prepare alginate hydrogels as monoliths and spheres, which can be further easily converted to high surface area aerogels. The aerogels obtained were further used as drug carriers. We investigated the effect of process parameters, such as starting concentration and viscosity of alginate solution, on synthesis products and on model drug (nicotinic acid) release. The results indicate that by using the internal setting cross-linking method for obtaining monolithic aerogels nicotinic acid was released in a more controlled manner. The aerogels thus obtained also exhibited smaller volume shrinkage than the ones described in other publications. However, with increasing alginate concentration in both types of synthesis more compact and cross-linked aerogels were formed.
Keywords: organic biodegradable gels, natural polysaccharides, aerogels, drug cariers
Published in DKUM: 01.06.2012; Views: 2435; Downloads: 110
URL Link to full text

Search done in 0.04 sec.
Back to top
Logos of partners University of Maribor University of Ljubljana University of Primorska University of Nova Gorica