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Hypodontia phenotype in patients with epithelial ovarian cancer
Anita Fekonja, Andrej Čretnik, Danijel Žerdoner, Iztok Takač, 2015, original scientific article

Abstract: Background: Ovarian cancer is usually diagnosed in an advanced stage and the present clinical and diagnostic molecular markers for early OC screening are insufficient. The aim of this study was to identify potential relationship between the hypodontia and epithelial ovarian cancer (EOC). Patients and methods: A retrospective study was conducted on 120 patients with EOC treated at the Department of Gynaecologic and Breast Oncology at the University Clinical Centre and 120 gynaecological healthy women (control group) of the same mean age. Women in both groups were reviewed for the presence of hypodontia and the patients with EOC also for clinicopathological characteristics of EOC according to hypodontia phenotype. Results: Hypodontia was diagnosed in 23 (19.2%) of patients with EOC and 8 (6.7%) controls (p = 0.004; odds ratio [OR] = 3.32; confidence interval [CI], 1.42-7.76). There was no statistically significant difference in patients with EOC with or without hypodontia regarding histological subtype (p = 0.220); they differed in regard to FIGO stage (p = 0.014; OR =3.26; CI, 1.23%8.64) and tumour differentiation grade (p = 0.042; OR = 3.1; CI, 1.01-9.53). Also, bilateral occurrence of EOC was more common than unilateral occurrence in women with hypodontia (p = 0.021; OR = 2.9; CI, 1.15-7.36). We also found statistically significant difference between the ovarian cancer group and control group in presence of other malignant tumours in subjects (p < 0.001). Conclusions: The results of the study suggest a statistical association between EOC and hypodontia phenotype. Hypodontia might serve as a risk factor for EOC detection.
Keywords: hypodontia, epithelial ovarian cancer, risk factor, early stage diagnosis
Published: 30.12.2015; Views: 510; Downloads: 147
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3.
Zastrupitev z etilenglikolom
Nina Hojs, Robert Ekart, Franc Svenšek, 2011, professional article

Abstract: Zastrupitve z etilenglikolom so dokaj redke. Etilenglikol je sam po sebi malo toksičen, hudo zastrupitev povzročajo predvsem njegovi presnovni produkti. Prikazani primer obravnava značilno klinično sliko (nevrološka, kardiopulmonalna in ledvična faza) in laboratorijske rezultate (povišana serumska osmolalnost, povišana osmolalna vrzel, metabolična acidoza s povišano anionsko vrzeljo, kristali kalcijevega oksalata v urinu) ob zastrupitvi z etilenglikolom. Hitra prepoznava je nujna, saj sta obolevnost in smrtnost po zastrupitvi visoki. Zdravljenje vključuje vzdrževanje dihalne poti, dihanja in krvnega obtoka, infuzijo bikarbonata, dajanje antidota (etanol, fomepizol), hemodializo, včasih tudi zdravljenje s kofaktorji presnove etilenglikola (tiamin, piridoksin, magnezij).
Keywords: Acid-Base Equilibrium, Acido-bazno ravnotežje, diagnosis, Diagnostika, Emergency Treatment, Ethylene Glycol, Etilenglikol, klinična slika, Nujno ukrepanje, Osmolar Concentration, Osmolarna koncentracija, poisoning, therapy, Zastrupitve, Zdravljenje
Published: 30.12.2015; Views: 1280; Downloads: 59
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4.
Prirojene motnje presnove v obdobju novorojenčka
Silva Burja, 2012, review article

Abstract: Kadar pri akutno in težje obolelem novorojenčku nimamo zanesljive diagnoze, moramo pomisliti tudi na možnost prirojene motnje presnove. Poleg skrbne anamneze in natančnega kliničnega pregleda so za diagnozo potrebni tudi biokemični in molekularno genetični testi. Osnovne diagnostične preiskave krvi(kompletna krvna slika, elektroliti, glukoza, mikroacidobazno ravnotežje, kreatin-kinaza, trigliceridi, laktat in amoniak) ter urina (glukoza, beljakovine in ketonska telesa) nam dajo prve informacije o vrsti presnovne motnje, kar terja nadaljnjo specifično diagnostiko. Vse metabolične bolezni skupaj zajemajo najmanj 1 % vseh novorojenčkov, kar bi za Slovenijo pomenilo okoli 200 otrok letno. Velika večina otrok s prirojeno presnovno boleznijo ostane neprepoznana. Pravočasna prepoznava teh bolezni bi lahko v marsikaterem primeru sprožila pravočasno zdravljenje. Normalen rezultat neonatalnega presejanja ne izključuje možnosti prirojene presnovne bolezni, saj z njim odkrivamo le omejeno število teh bolezni.
Keywords: Diagnosis, Diagnostika, Dojenček, novorojenček, Infant, Newborn, Metabolism, Inborn Errors, metabolizem, Metabolizem, prirojene motnje, novorojenček, presnovne motnje
Published: 30.12.2015; Views: 630; Downloads: 29
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5.
Nanotechnology in food safety and quality assessment
Maša Primec, 2016, review article

Abstract: A rapid microbial detection in different biological and environmental material is a key of preventing several foodborne diseases. By implementing nanotechnology into food safety sector, a great step towards successful, reliable and sensible detection methods of foodborne pathogens has been achieved. Therefore, the aim of this review was to illustrate some of the principal functions of nanotechnology-based techniques, used for microbial detection in the last few years. Regarding consumer’s health, the review also discusses the question of safety, concerning human exposure to nanomaterials (NMs). Due to their different composition-unique properties, such as greater penetrability, reactivity and high surface to volume ratio, NMs have been coupled to several biomolecules and integrated in special system devices, resulting in improvement of sensitivity in transmitting biological signal informations in a shorter time. Among all the NMs, gold, magnetic and fluorescent nanoparticles (NPs) have been widely used, also in microbial diagnosis. Despite the success of linking nanotechnology to detection of foodborne pathogens, the exposure to various NMs could also be a matter of potential risk to human health, although conclusions still need to be definitely proven.
Keywords: nanotechnology, food safety, nanoparticles, diagnosis, foodborne pathogens
Published: 14.11.2017; Views: 318; Downloads: 41
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