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1.
Optimal kinematic design of a link-drive mechanism with prescribed velocity characteristics
Bojan Vohar, Karl Gotlih, Jože Flašker, 2003, short scientific article

Abstract: The paper presents an example of a link-drive mechanism for a deep drawing mechanical press. Because of its characteristics such a drive is much more appropriate than conventional crankshaft or eccentric drive. The existing design of the drive has proved unsatisfactory and does not meet all the demands and constraints, which are ideal for deep drawing process. Optimization of the drive is therefore necessary. The intention is to achieve the required velocity characteristics in a defined area of movement. Firstly, the drive is analyzed and a mathematical model is made and prepared for optimization procedure. The process is time-dependent, so it cannot be used directly in the optimization algorithm. Mathematical model is transformed intoa form suitable for the standard non-linear optimization procedure and then optimization is carried out. The method used is sequential quadratic programming. The final objective of the optimization process is to find such dimensions of link-drive members that the given requirements are satisfied in the best possible manner.
Keywords: mechanics, dynamics of mechanical systems, closed kinematic chains, mathematical modelling, non-linear optimization, drive optimization, drive dimensioning, kinematic analysis, link-drive mechanism, deep drawing press
Published: 01.06.2012; Views: 1330; Downloads: 66
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MLC-kinase/phosphatase control of Ca[sup]2+ signal transduction in airway smooth muscles
Aleš Fajmut, Milan Brumen, 2008, original scientific article

Abstract: In airway smooth muscles, kinase/phosphatase-dependent phosphorylation and dephosphorylation of the myosin light chain (MLC) have been revealed by many authors as important steps in calcium ▫$(Ca^{2+})$▫ signalling pathway from the variation of ▫$Ca^{2+}$▫ concentration in cytosol to the force development. Here, a theoretical analysis of the control action of MLC-kinase (MLCK) and MLC-phosphatase (MLCP) in ▫$Ca^{2+}$▫ signalling is presented and related to the general control principles of these enzymes, which were previously studied by Reinhart Heinrich and his co-workers. The kinetic scheme of the mathematical model considers interactions among ▫$Ca^{2+}$▫, calmodulin (CaM) and MLCK and the well-known 4-state actomyosin latch bridge model, whereby a link between them is accomplished by the conservation relation of all species of MLCK. The mathematical model predicts the magnitude and velocity of isometric force in smooth muscles upon transient biphasic ▫$Ca^{2+}$▫ signal. The properties of signal transduction in the system such as the signalling time, signal duration and signal amplitude, which are reflected in the properties of force developed, are studied by the principles of the metabolic control theory. The analysis of our model predictions confirms as shown by Reinhart Heinrich and his co-workers that MLCK controls the amplitude of signal more than its duration, whereas MLCP controls both. Finally, the simulations of elevated total content of MLCK, a typical feature of bronchial muscles of asthmatic subjects and spontaneously hypertensive rats as well as potentiation of MLCP catalytic activity, are carried out and are discussed in view of an increase in the force magnitude.
Keywords: cells, calcium, calcium oscillations, myosin light chains, enzyme activities, mathematical models
Published: 07.06.2012; Views: 1097; Downloads: 9
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Integration of travel agencies with other supply chain members
Darja Topolšek, Dejan Dragan, 2016, original scientific article

Abstract: The performance of tourism supply chains depends on the efficiency of all members involved, including the travel agencies. The paper addresses the analysis of relationships between the agencies' external integration with other supply chain members on one side, and the efficiency of the agencies on the other. The data envelopment analysis is applied for the estimation of efficiencies, while the structural equation modelling (SEM) is conducted for identification of possible integration impacts on the efficiency. Results show that integration with other supply chain members indeed has some positive impacts on the agencies' efficiency. Also, the developed SEM model implies that in-depth forms of collaboration would enable more effective exploitation of the identified relations between the integration and efficiency of the agencies. This finding could be an important guideline for the agencies' management in the sense of achieving more satisfied customers and bigger profits, as well as reduced operational costs.
Keywords: tourism sector, supply chains, structural equation modeling, external integration, efficiency, travel agencies, logistics
Published: 03.04.2017; Views: 229; Downloads: 42
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Competitiveness by requisitely holistic and innovative logistic management
Matjaž Knez, Bojan Rosi, Matjaž Mulej, Martin Lipičnik, 2010, review article

Abstract: In the age of global expansion of business operations and contemporary way of life the material and information flows in and between different companies are growing rapidly; they are thus becoming more and more difficult to manage. Had business functions in companies been dealt with separately until now (purchase, production, finances, sale, etc.), today the emphasis is placed on their integration due to their interdependence. By studying supply chains inside and between business partners, companies can gain competitive advantage and become more adjustable, taking the increasingly changing market circumstances into account. This enables them to meet consumers' demands and expectations requisitely holistically. Taking all the crucial activities into account, the logistics management plays a key role in the companies facing the challenges of the new millennium. Based on the numerous megatrends, which influence each and every business entity, this article aims to explain the increasing strategic importance of logistics management. The latter may not be dealt with one-sidedly as a cost; moreover, the key aspects such as competitiveness as well as long-term existence of a company must also be considered. Innovation and systemic thinking in it and about it are needed.
Keywords: logistics management, logistics strategy, supply chains, megatrends, innovation, systemic thinking
Published: 01.06.2017; Views: 334; Downloads: 122
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Dynamic optimization in supply chains
Drago Pupavac, Jasmina Pašagić Škrinjar, Ratko Zelenika, 2007, original scientific article

Abstract: Production and stock optimization in supply chains is a complex problem because it determines the optimum quantity production in time. Due to their multileveld nature, those problems are mostly solved by different methods and models of dynamic programming. The problem discussed in this paper refers to the determination of optimum quantity of production and stocks within the supply chain in a certain period of time, as well as in each sub-interval of a period, but with the condition that the production and stock expenditure remains minimal and that the predetermined demand in every sub-interval and throughout the entire observation period remains satisfied.
Keywords: transportation, logistics, transportation networks, supply chains, optimization, dynamic programming, traffic
Published: 02.06.2017; Views: 322; Downloads: 51
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10.
Influence of relationship commitment and trust on collaborative behaviour in supply chains
Sonja Mlaker Kač, Irena Gorenak, Vojko Potočan, 2015, original scientific article

Abstract: The paper discusses theoretically and examines empirically the influence of the relationship commitment on collaborative behaviour in supply chains. In today's unstable business environment companies should collaborate to achieve mutual goals and competitive advantage. Defining relationship commitment and collaboration in supply chains (from social exchange theory point of view) is the basis of the research of this paper. Our aim is to examine the influence of relationship commitment on collaboration in supply chains in Slovenian economy. The qualitative research part discusses if the relationship commitment between partners in supply chain influences the collaborative behaviour between partners and which are the antecedents of relationship commitment. The research is based on a quantitative analysis of the online questionnaire survey made on the Slovenian economy. The research results show strong influence of trust and relationship commitment on collaboration between partners in supply chains.
Keywords: business ethics, relationship commitment, trust, collaborative behaviour, supply chains
Published: 02.06.2017; Views: 333; Downloads: 156
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