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Urinary metabolic biomarker profiling for cancer diagnosis by terahertz spectroscopy : review and perspective
Andreja Abina, Tjaša Korošec, Uroš Puc, Mojca Jazbinšek, Aleksander Zidanšek, 2023, review article

Abstract: In the last decade, terahertz (THz) technologies have been introduced to the detection, identification, and quantification of biomolecules in various biological samples. This review focuses on substances that represent important biomarkers in the urine associated with various cancers and their treatments. From a diagnostic point of view, urine liquid biopsy is particularly important because it allows the non-invasive and rapid collection of large volumes of samples. In this review, the THz spectral responses of substances considered metabolic biomarkers in urine and obtained in previous studies are collected. In addition, the findings from the relatively small number of prior studies that have already been carried out on urine samples are summarised. In this context, we also present the different THz methods used for urine analysis. Finally, a brief discussion is given, presenting perspectives for future research in this field, interpreted based on the results of previous studies. This work provides important information on the further application of THz techniques in biomedicine for detecting and monitoring urinary biomarkers for various diseases, including cancer.
Keywords: terahertz spectroscopy, urinary biomarkers, metabolic biomarkers, cancer diagnostics, biomolecules, non-invasive detection, biomedical detection
Published in DKUM: 14.03.2024; Views: 134; Downloads: 20
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UCHL1, besides leptin and fibronectin, also could be a sensitive marker of the relapsing–remitting type of multiple sclerosis
Ewelina Görska, Marzena Tylicka, Adam Hermanowicz, Ewa Matuszczak, Anna Sankiewicz, Ewa Gorodkiewicz, Justyna Hermanowicz, Elźbieta Karpińska, Katarzyna Socha, Jan Kochanowicz, Evgenija Homšak, 2023, original scientific article

Abstract: Research on the markers of immunoregulatory response in multiple sclerosis (MS) is still of great importance. The aim of our study was the evaluation of leptin, fibronectin, and UCHL1 concentrations as potential biomarkers of a relapsing-remitting type of MS (RRMS). Surface Plasmon Resonance Imaging (SPRI) biosensors were used for the evaluation of proteins concentrations in 100 RRMS patients and 46 healthy volunteers. Plasma leptin, fibronectin, and UCHL1 concentrations were significantly higher in RRMS patients compared to the control group (p < 0.001, respectively). UCHL1 concentration evaluation revealed the highest diagnostic sensitivity (100%) and negative predictive value (100%) in differentiating MS patients from healthy individuals. There was no significant difference in the UCHL1 concentrations depending on the patient's sex, the presence of relapse within the last 24 months, and the EDSS value (p > 0.05, respectively). In RRMS patients UCHL1 concentration positively correlated with fibronectin levels (r = 0.3928; p < 0.001). In the current cohort of patients plasma UCHL1 concentration was independent of the time of MS relapse and the severity of neurological symptoms. Thus current study may indicate that plasma UCHL1, besides leptin and fibronectin, also could be a promising high-sensitive potential biomarker of relapsing-remitting type of MS. However, these results should be validated with a larger group of patients, taking into account neuroimaging and cerebrospinal fluid analysis data, and by comparing them to patients with other neurological diseases as a control group.
Keywords: immunoregulatory response, multiple sclerosis, biomarkers, leptin, fibronectins, ubiquitin thiolesterase
Published in DKUM: 21.02.2024; Views: 220; Downloads: 13
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