1. Depression, anxiety, stress, and coping mechanisms among parents of children with autism spectrum disorderAjda Demšar, Karin Bakračevič, 2023, original scientific article Abstract: The purpose of the present study was to determine the level of stress, anxiety, and depression among Slovenian parents of children with autism spectrum disorder and their coping mechanisms. The study included 42 parents of children with ASD who were enrolled at a specialised clinic for children with hearing and speech difficulties. We used the Depression Anxiety Stress Scales (DASS), the Coping Orientation to Problems Experienced (COPE) inventory, and a demographic questionnaire which included questions on satisfaction with life and social support received. The respondents reported no clinically elevated levels of stress, depression or anxiety. However, the mothers reported more stress and anxiety related symptoms then did the fathers. The results showed that coping strategies of positive reinterpretation and growth were positively correlated to higher perceived social support and greater satisfaction with life, and were negatively correlated with depression and anxiety. Perceived social support was highly negatively correlated with anxiety. Strategies of acceptance were used significantly more often by individuals with a higher level of education.
Keywords: anxiety, autism spectrum disorders, stress coping, parents, social support
Published in DKUM: 31.05.2024; Views: 176; Downloads: 7
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2. Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain : a transdiagnostic multimodal meta-analysis of structural and functional MRI studiesFelix Brandl, Benedikt Weise, Satja Mulej Bratec, Nazia Jassim, Daniel Hoffmann Ayala, Teresa Bertram, Markus Ploner, Christian Sorg, 2022, original scientific article Abstract: Major depressive disorder (MDD), anxiety disorders (ANX), and chronic pain (CP) are closely-related disorders with both high degrees of comorbidity among them and shared risk factors. Considering this multi-level overlap, but also the distinct phenotypes of the disorders, we hypothesized both common and disorder-specific changes of large-scale brain systems, which mediate neural mechanisms and impaired behavioral traits, in MDD, ANX, and CP. To identify such common and disorder-specific brain changes, we conducted a transdiagnostic, multimodal meta-analysis of structural and functional MRI-studies investigating changes of gray matter volume (GMV) and intrinsic functional connectivity (iFC) of large-scale intrinsic brain networks across MDD, ANX, and CP. The study was preregistered at PROSPERO (CRD42019119709). 320 studies comprising 10,931 patients and 11,135 healthy controls were included. Across disorders, common changes focused on GMV-decrease in insular and medial-prefrontal cortices, located mainly within the so-called default-mode and salience networks. Disorder-specific changes comprised hyperconnectivity between defaultmode and frontoparietal networks and hypoconnectivity between limbic and salience networks in MDD; limbic network hyperconnectivity and GMV-decrease in insular and medial-temporal cortices in ANX; and hypoconnectivity between salience and default-mode networks and GMV-increase in medial temporal lobes in CP. Common changes suggested a neural correlate for comorbidity and possibly shared neuro-behavioral chronification mechanisms. Disorder-specific changes might underlie distinct phenotypes and possibly additional disorder-specific mechanisms.
Keywords: human threat behaviour, major depressive disorder, anxiety disorders, chronic pain, structural MRI, functional MRI
Published in DKUM: 18.08.2023; Views: 422; Downloads: 29
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3. Comorbidities and characteristics of coronary heart disease patients: their impact on health-related quality of lifeKsenija Tušek-Bunc, Davorina Petek, 2016, original scientific article Abstract: Background: Patients with coronary heart disease (CHD) commonly present with more than one comorbid condition, contributing to poorer health-related quality of life (HRQoL). The aim of our study was to identify the associations between HRQoL and patient characteristics, vascular comorbidities and anxiety/depression disorders.
Methods: This observational study was conducted in 36 family medicine practices selected by random stratified sampling from all regions of Slovenia. HRQoL was assessed using the European Quality of Life - 5 Dimensions (EQ-5D) questionnaire and EQ Visual Analogue Scale (EQ-VAS). The associations between HRQoL and patient characteristics stratified by demographics, vascular comorbidities, health services used, their assessment of chronic illness care, and anxiety/depression disorders were identified by ordinal logistic regression and linear regression models.
Results: The final sample included 423 CHD patients with a mean age of 68.0 ± SD 10.8 years; 35.2% were female. Mean EQ-VAS score was 58.6 ± SD 19.9 (median: 60 with interquartile range of 45–75), and mean EQ-5D index was 0.60 ± SD 0.19 (median: 0.56 with interquartile range of 0.41–0.76). The statistically significant predictors of a lower EQ-VAS score were higher family physician visit frequency, heart failure (HF) and anxiety/depression disorders (R² 0.240; F = 17.368; p < 0.001). The statistically significant predictor of better HRQoL, according to EQ-5D was higher patient education, whereas higher family physician visit frequency, HF and peripheral artery disease (PAD) were predictors of poorer HRQoL (Nagelkerke R 2 = 0.298; χ 2 = 148.151; p < 0.001).
Conclusions: Results of our study reveal that comorbid conditions (HF and PAD), family physician visit frequency and years in education are significant predictors of HRQoL in Slovenian CHD patients.
Keywords: coronary heart disease patient, health-related quality of life, vascular comorbidities, anxiety/depression disorders
Published in DKUM: 29.06.2017; Views: 1747; Downloads: 421
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