1. Beneficial effects of castanea sativa wood extract on the human body and possible food and pharmaceutical applicationsTaja Žitek Makoter, Mojca Tancer Verboten, Ivan Mirt, Katarina Zupančić, Darija Cör Andrejč, Željko Knez, Maša Knez Marevci, 2024, review article Abstract: The aim of this review was to investigate the potential use of Castanea sativa wood extract
as a food supplement and to evaluate its beneficial properties for human health. The results of the
limited amount of studies suggest promising properties, including potential anti-inflammatory effects.
The literature indicates that the extract, which is rich in bioactive compounds such as tannins, offers
promising therapeutic possibilities for the treatment of conditions associated with chronic inflammation. Consequently, interest in its use in food and pharmaceuticals is growing. Phytochemical
studies have reported antioxidant and antimicrobial activities, and anti-inflammatory, anticancer,
hypolipidemic, hypoglycemic, and neuroprotective activities. A suitable extraction method and
solvent is crucial for the isolation of bioactive compounds, being green extraction technologies outstanding for the industrial recovery of chestnut wood’s bioactive compounds. Nevertheless, it is
important to emphasize the importance of adhering to regulatory guidelines and obtaining the necessary approvals from regulatory authorities to ensure product safety and compliance. The regulation
of herbal medicinal products with proven efficacy and traditional herbal medicinal products is well
defined, monitored by authorized bodies, and subject to strict control measures. It is noteworthy
that medicinal products are subject to stringent quality testing to ensure safety and efficacy in use,
whereas there are no comparable regulatory standards and specific labeling requirements for dietary
supplements. When using herbal products, compliance with established standards in health research
is essential.
Keywords: Castanea sativa, wood extracts, tannins, antioxidat activity, anti-inflammatory activity, antimicrobial activity
Published in DKUM: 30.07.2025; Views: 0; Downloads: 7
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2. Green techniques for preparation of red beetroot extracts with enhanced biological potentialDragana Borjan, Vanja Šeregelj, Darija Cör Andrejč, Lato Pezo, Vesna Tumbas Šaponjac, Željko Knez, Jelena J. Vulić, Maša Knez Marevci, 2022, original scientific article Abstract: Red beetroot is well known for its high proportion of betalains, with great potential as functional food ingredients due to their health-promoting properties. The objective of this study was to investigate the influence of processing techniques such as Soxhlet, cold, ultrasound and supercritical fluid extraction on the betalains content and its antioxidant, anti-inflammatory and antihyperglycemic activities. Whilst Soxhlet extraction with water has provided the highest yield, the highest content of total phenolics was found in an extract prepared using Soxhlet extraction with 50% ethanol. Amongst eight phenolic compounds detected in the extracts, protocatechuic acid was the most abundant. The concentrations of total phenolics ranged from 12.09 mg/g (ultrasound extraction with 30% methanol) to 18.60 mg/g (Soxhlet extraction with 50% ethanol). The highest anti-inflammatory activity was observed for cold extraction with 50% methanol extract. The high radical scavenging activity of supercritical fluid extracts could be a consequence of nonphenolic compounds. The chemometrics approach was further used to analyse the results to find the “greenest” method for further possible application in the processing of beetroot in the food and/or pharmaceutical industry. According to the standard score, the best extraction method was determined to be Soxhlet extraction with 50% ethanol.
Keywords: red beetroot, supercritical fluid extraction, antioxidant activity, anti-inflammatory activity, antihyperglycemic activity, chemometric approach
Published in DKUM: 18.08.2023; Views: 436; Downloads: 132
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