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1.
Obolenja prebavil in nujna stanja v obdobju novorojenčka
Silva Burja, 2012, review article

Abstract: V skupini novorojenčkov z običajnimi prebavnimi težavami je tudi pomembna skupina otrok z zelo resnimi obolenji prebavil s kirurškimi diagnozami. Prispevek je osredotočen na tiste, ki jih najpogosteje srečamo v praksi in razpravlja o nekaterih potencialno ogrožajočih prirojenih anomalijah in drugih obolenjih prebavil, ki se pojavijo že v obdobju novorojenčka. Naš namen je bil poglobiti razpravo o tej problematiki s poudarki na pomembnosti hitrega in pravilnega ukrepanja v vsakodnevni praksi.
Keywords: Dojenček, novorojenček, Emergencies, Gastrointestinal Diseases, Gastrointestinalne bolezni, Infant, Newborn, novorojenčki, Nujna stanja, prebavila
Published: 30.12.2015; Views: 817; Downloads: 39
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2.
Prirojene motnje presnove v obdobju novorojenčka
Silva Burja, 2012, review article

Abstract: Kadar pri akutno in težje obolelem novorojenčku nimamo zanesljive diagnoze, moramo pomisliti tudi na možnost prirojene motnje presnove. Poleg skrbne anamneze in natančnega kliničnega pregleda so za diagnozo potrebni tudi biokemični in molekularno genetični testi. Osnovne diagnostične preiskave krvi(kompletna krvna slika, elektroliti, glukoza, mikroacidobazno ravnotežje, kreatin-kinaza, trigliceridi, laktat in amoniak) ter urina (glukoza, beljakovine in ketonska telesa) nam dajo prve informacije o vrsti presnovne motnje, kar terja nadaljnjo specifično diagnostiko. Vse metabolične bolezni skupaj zajemajo najmanj 1 % vseh novorojenčkov, kar bi za Slovenijo pomenilo okoli 200 otrok letno. Velika večina otrok s prirojeno presnovno boleznijo ostane neprepoznana. Pravočasna prepoznava teh bolezni bi lahko v marsikaterem primeru sprožila pravočasno zdravljenje. Normalen rezultat neonatalnega presejanja ne izključuje možnosti prirojene presnovne bolezni, saj z njim odkrivamo le omejeno število teh bolezni.
Keywords: Diagnosis, Diagnostika, Dojenček, novorojenček, Infant, Newborn, Metabolism, Inborn Errors, metabolizem, Metabolizem, prirojene motnje, novorojenček, presnovne motnje
Published: 30.12.2015; Views: 1233; Downloads: 47
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3.
Exocytosis of insulin in vivo maturation of mouse endocrine pancreas
Aldo Rozzo, Tiziana Meneghel-Rozzo, Saška Lipovšek Delakorda, Shi-Bing Yang, Marjan Rupnik, 2009, published scientific conference contribution

Abstract: The aim of this study was to define when an insulin-positive cell becomes functional in vivo and starts to exocytose insulin in a regulated nutrient-dependent manner. Insulin-positive cells appear in embryonic life (midgestation) and complete their maturation, presumably around birth. In order to work with embryonic and newborn endocrine pancreas, we used organotypic slices. The mouse embryonic pancreas slices show high basal insulin release that is not further elevated by high glucose levels. Despite the presence of functional voltage-activated ion channels, the cells are not electrically active in the presence of secretagogues. At birth, the high basalinsulin release drops and, after postnatal day 2, the insulin-positive cells show both adult-like bursting electrical activity and hormone release induced by high glucose levels. These properties allowed us to define them as beta cells. Despite the apparent stability of the transcription factor profile reported in insulin-positive cells during late-embryonic life, functional beta cells appear only 2 days after birth.
Keywords: cell biology, insulin release, embrios, newborn, beta-cell maturation, developing pancreas
Published: 07.06.2012; Views: 960; Downloads: 19
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