1. Multimodal observable cues in mood, anxiety, and borderline personality disorders: a review of reviews to inform explainable AI in mental healthGrega Močnik, Ana Rehberger, Žan Smogavc, Izidor Mlakar, Urška Smrke, Sara Močnik, 2025, review article Abstract: Mental health disorders, such as depression, anxiety, and borderline personality disorder (BPD), are common, often begin early, and can cause profound impairment. Traditional assessments rely heavily on subjective reports and clinical observation, which can be inconsistent and biased. Recent advances in AI offer a promising complement by analyzing objective, observable cues from speech, language, facial expressions, physiological signals, and digital behavior. Explainable AI ensures these patterns remain interpretable and clinically meaningful. A synthesis of 24 recent systematic and scoping reviews shows that depression is linked to self-focused negative language, slowed and monotonous speech, reduced facial expressivity, disrupted sleep and activity, and altered phone or online behavior. Anxiety disorders present with negative language bias, monotone speech with pauses, physiological hyperarousal, and avoidance-related behaviors. BPD exhibits more complex patterns, including impersonal or externally focused language, speech dysregulation, paradoxical facial expressions, autonomic dysregulation, and socially ambivalent behaviors. Some cues, like reduced heart rate variability and flattened speech, appear across conditions, suggesting shared transdiagnostic mechanisms, while BPD’s interpersonal and emotional ambivalence stands out. These findings highlight the potential of observable, digitally measurable cues to complement traditional assessments, enabling earlier detection, ongoing monitoring, and more personalized interventions in psychiatry. Keywords: observable cues, mood disorders, anxiety disorders, borderline personality disorder, multimodal signals, facial expressions, speech patterns, physiological signals, explainable AI, mental health assessment Published in DKUM: 05.01.2026; Views: 0; Downloads: 1
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2. A randomized pilot study evaluating socially assistive robot effects on patient engagement and care qualityIzidor Mlakar, Urška Smrke, Valentino Šafran, Igor Robert Roj, Bojan Ilijevec, Samo Horvat, Vojko Flis, Nejc Plohl, 2025, original scientific article Abstract: Healthcare faces significant challenges, including workforce shortages and increasing demands. Socially assistive robots (SARs) have emerged as potential solutions to augment care, but their implementation in hospital wards remains largely unexplored. We conducted a randomized external pilot study (ISRCTN Registry, ISRCTN96689284, registered 24/02/2022) evaluating SAR intervention feasibility and effects on patient engagement and perceived quality of care (co-primary outcomes) and health-related quality of life (secondary outcome) in surgical wards. Patients (N = 229) at University Medical Center Maribor were allocated to SAR intervention (standard care + SAR) or control groups (standard care only). The SAR utilized validated, story-driven conversational capabilities providing standardized patient education, support, and basic triage through predefined dialog flows. While overall effects on patient engagement and perceived care quality were limited, the intervention showed positive impact on pain management. Contextual factors moderated intervention effects, highlighting SAR potential in specific domains. No substantial negative effects were detected. High retention rates demonstrated practical feasibility of SAR implementation in surgical settings. Keywords: healthcare, socially assistive robots, SARs Published in DKUM: 08.12.2025; Views: 0; Downloads: 1
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3. Feasibility of a computerized clinical decision support system delivered via a socially assistive robot during grand rounds : a pilot studyValentino Šafran, Urška Smrke, Bojan Ilijevec, Samo Horvat, Vojko Flis, Nejc Plohl, Izidor Mlakar, 2025, original scientific article Abstract: Aims and Objective: The aim of this study was to explore the feasibility, usability and acceptance of integrating Clinical Decision Support Systems with Socially Assistive Robots into hospital grand rounds. Background: Adopting Clinical Decision Support Systems in healthcare faces challenges such as complexity, poor integration with workflows, and concerns about data privacy and quality. Issues such as too many alerts, confusing errors, and difficulty using the technology in front of patients make adoption challenging and prevent it from fitting into daily workflows. Making Clinical Decision Support System simple, intuitive and user-friendly is essential to enable its use in daily practice to improve patient care and decision-making. Methods: This six-month pilot study had two participant groups, with total of 40 participants: a longitudinal intervention group (n =8) and a single-session evaluation group (n=32). Participants were medical doctors at the University Clinical Center Maribor. The intervention involved implementing a Clinical Decision Support System delivered via a Socially Assistive Robot during hospital grand rounds. We developed a system that employed the HL7 FHIR standard for integrating data from hospital monitors, electronic health records, and patient-reported outcomes into a single dashboard. A Pepper-based SAR provided patient specific recommendations through a voice and SAR tablet enabled interface. Key evaluation metrics were assessed using the System Usability Scale (SUS) and the Unified Theory of Acceptance, Use of Technology (UTAUT2) questionnaire, including Effort Expectancy, Performance Expectancy and open ended questions. The longitudinal group used the system for 6 months and completed the assessments twice, after one week and at the end of the study. The single-session group completed the assessment once, immediately after the experiment. Qualitative data were gathered through open-ended questions. Data analysis included descriptive statistics, paired t-tests, and thematic analysis. Results: System usability was rated highly across both groups, with the longitudinal group reporting consistently excellent scores (M =82.08 at final evaluation) compared to the acceptable scores of the single-session group (M =68.96). Extended exposure improved user engagement, reflected in significant increases in Effort Expectancy and Habit over time. Participants found the system enjoyable to use, and while no significant changes were seen in Performance Expectancy, feedback emphasized its efficiency in saving time and improving access to clinical data, supporting its feasibility and acceptability. Conclusions: This research supports the potential of robotic technologies to transform CDSS into more interactive, efficient, and user-friendly tools for healthcare professionals. The paper also suggests further research directions and technical improvements to maximize the impact of innovative technologies in healthcare. Keywords: clinical decision support systems, clinical decision-making, hospital grand rounds, patient data integration, perceived quality of care, socially assistive robots, usability and familiarity, user experience questionnaire, workload reduction Published in DKUM: 30.05.2025; Views: 0; Downloads: 3
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4. Facilitating acceptance, trust, and ethical integration of socially assistive robots among nurses : a quasi-experimental studyIzidor Mlakar, Igor Robert Roj, Vojko Flis, Valentino Šafran, Urška Smrke, 2025, original scientific article Abstract: Objectives: To evaluate the impact of different types of demonstrations (no demonstration, video demonstration, and face-to-face demonstration) on nurses’ acceptance, trust, and ethical considerations regarding socially assistive robots. Methods: The study employed a quasi-experimental design involving 312 nurses: 201 with no exposure to socially assistive robots, 97 exposed via video demonstrations, and 14 exposed through live face-to-face demonstrations in a hospital room. Participants completed self-report measures assessing their perceptions of ethical acceptability, trust, and acceptance of socially assistive robots. Results: Participants exposed to any kind of demonstration reported significantly higher perceptions of ethical acceptability compared to those with no exposure. Among demonstration types, live face-to-face demonstrations resulted in higher overall ethical acceptability, satisfaction, and acceptance compared to video demonstrations. Conclusions: Demonstrations, particularly face-to-face interactions, play a crucial role in fostering ethical acceptability and overall acceptance of socially assistive robots. These findings highlight the importance of incorporating live demonstrations in strategies to improve healthcare professionals’ trust and acceptance of robotic technology. Keywords: ethical acceptability, acceptance, socially assistive robots, nurses, quasi experimental study Published in DKUM: 29.05.2025; Views: 0; Downloads: 2
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5. Evaluating the benefits and implementation challenges of digital health interventions for improving self-efficacy and patient activation in cancer survivors : single-case experimental prospective studyUmut Arioz, Urška Smrke, Valentino Šafran, Maja Ravnik, Matej Horvat, Vojko Flis, Izidor Mlakar, 2025, original scientific article Abstract: Cancer survivors face numerous challenges, and digital health interventions can empower them by enhancing self-efficacy and patient activation. This prospective study aimed to assess the impact of a mHealth app on self-efficacy and patient activation in 166 breast and colorectal cancer survivors. Participants received a smart bracelet and used the app to access personalized care plans. Data were collected at baseline and follow-ups, including patient-reported outcomes and clinician feedback. The study demonstrated positive impacts on self-efficacy and patient activation. The overall trial retention rate was 75.3%. Participants reported high levels of activation (PAM levels 1–3: P = 1.0; level 4: P = 0.65) and expressed a willingness to stay informed about their disease (CASE-Cancer factor 1: P = 0.98; factor 2: P = 0.66; factor 3: P = 0.25). Usability of the app improved, with an increase in participants rating the system as having excellent usability (from 14.82% to 22.22%). Additional qualitative analysis revealed positive experiences from both patients and clinicians. This paper contributes significantly to cancer survivorship care by providing personalized care plans tailored to individual needs. The PERSIST platform shows promise in improving patient outcomes and enhancing self-management abilities in cancer survivors. Further research with larger and more diverse populations is needed to establish its effectiveness. Keywords: cancer survivorship, self-efficacy, satisfaction, patient activation, digital health interventions Published in DKUM: 25.04.2025; Views: 0; Downloads: 0 |
6. Exploring the feasibility of generative AI in persona research : a omparative analysis of large language model-generated and human-crafted personas in obesity researchUrška Smrke, Ana Rehberger, Nejc Plohl, Izidor Mlakar, 2025, original scientific article Abstract: This study investigates the perceptions of Persona descriptions generated using three different large language models (LLMs) and qualitatively developed Personas by an expert panel involved in obesity research. Six different Personas were defined, three from the clinical domain and three from the educational domain. The descriptions of Personas were generated using qualitative methods and the LLMs (i.e., Bard, Llama, and ChatGPT). The perception of the developed Personas was evaluated by experts in the respective fields. The results show that, in general, the perception of Personas did not significantly differ between those generated using LLMs and those qualitatively developed by human experts. This indicates that LLMs have the potential to generate a consistent and valid representation of human stakeholders. The LLM-generated Personas were perceived as believable, relatable, and informative. However, post-hoc comparisons revealed some differences, with descriptions generated using the Bard model being in several Persona descriptions that were evaluated most favorably in terms of empathy, likability, and clarity. This study contributes to the understanding of the potential and challenges of LLM-generated Personas. Although the study focuses on obesity research, it highlights the importance of considering the specific context and the potential issues that researchers should be aware of when using generative AI for generating Personas. Keywords: user personas, obesity, large language models, value sensitive design, digital health interventions Published in DKUM: 14.02.2025; Views: 0; Downloads: 12
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7. Decoding anxiety : a scoping review of observable cuesUrška Smrke, Izidor Mlakar, Ana Rehberger, Leon Žužek, Nejc Plohl, 2024, review article Abstract: Background: While anxiety disorders are one of the most prevalent mental diseases, they are often overlooked due to shortcomings of the existing diagnostic procedures, which predominantly rely on self-reporting. Due to recent technological advances, this source of information could be complemented by the so-called observable cues – indicators that are displayed spontaneously through individuals’ physiological responses or behaviour and can be detected by modern devices. However, while there are several individual studies on such cues, this research area lacks a synthesis. In line with this, our scoping review aimed to identify observable cues that offer meaningful insight into individuals’ anxiety and to determine how these cues can be measured. Methods: We followed the PRISMA guidelines for scoping reviews. The search string containing terms related to anxiety and observable cues was entered into four databases (Web of Science, MEDLINE, ERIC, IEEE). While the search – limited to English peer-reviewed records published from 2012 onwards – initially yielded 2311 records, only 33 articles fit our selection criteria and were included in the final synthesis. Results: The scoping review unravelled various categories of observable cues of anxiety, specifically those related to facial expressions, speech and language, breathing, skin, heart, cognitive control, sleep, activity and motion, location data and smartphone use. Moreover, we identified various approaches for measuring these cues, including wearable devices, and analysing smartphone usage and social media activity. Conclusions: Our scoping review points to several physiological and behavioural cues associated with anxiety and highlights how these can be measured. These novel insights may be helpful for healthcare practitioners and fuel future research and technology development. However, as many cues were investigated only in a single study, more evidence is needed to generalise these findings and implement them into practice with greater confidence. Keywords: anxiety, observable cues, digital biomarkers, scoping review, physiological cues, behavioural cues Published in DKUM: 07.02.2025; Views: 0; Downloads: 7
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8. An end-to-end framework for extracting observable cues of depression from diary recordingsIzidor Mlakar, Umut Arioz, Urška Smrke, Nejc Plohl, Valentino Šafran, Matej Rojc, 2024, original scientific article Abstract: Because of the prevalence of depression, its often-chronic course, relapse and associated disability, early detection and non-intrusive monitoring is a crucial tool for timely diagnosis and treatment, remission of depression and prevention of relapse. In this way, its impact on quality of life and well-being can be limited. Current attempts to use artificial intelligence for the early classification of depression are mostly data-driven and thus non-transparent and lack effective means to deal with uncertainties. Therefore, in this paper, we propose an end-to-end framework for extracting observable depression cues from diary recordings. Furthermore, we also explore its feasibility for automatic detection of depression symptoms using observable behavioural cues. The proposed end-to-end framework for extracting depression was used to evaluate 28 video recordings from the Symptom Media dataset and 27 recordings from the DAIC-WOZ dataset. We compared the presence of the extracted features between recordings of individuals with and without a depressive disorder. We identified several cues consistent with previous studies in terms of their differentiation between individuals with and without depressive disorder across both datasets among language (i.e., use of negatively valanced words, use of first-person singular pronouns, some features of language complexity, explicit mentions of treatment for depression), speech (i.e., monotonous speech, voiced speech and pauses, speaking rate, low articulation rate), and facial cues (i.e., rotational energy of head movements). The nature/context of the discourse, the impact of other disorders and physical/psychological stress, and the quality and resolution of the recordings all play an important role in matching the digital features to the relevant background. In this way, the work presented in this paper provides a novel approach to extracting a wide range of cues relevant to the classification of depression and opens up new opportunities for further research. Keywords: digital biomarkers of depression, facial cues, speech cues, language cues, deep learning, end-to-end pipeline, artificial intelligence Published in DKUM: 17.01.2025; Views: 0; Downloads: 13
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9. Quality of life of colorectal cancer survivors : mapping the key indicators by expert consensus and measures for their assessmentUrška Smrke, Sara Abalde-Cela, Catherine Loly, Jean-Paul Calbimonte, Liliana Pires, Simon Lin, Alberto Sánchez, Sara Tement, Izidor Mlakar, 2024, original scientific article Keywords: quality of life, surveys and questionnaires, adult oncology, colorectal cancer survivors, Delphi study, scoping review, expert consensus Published in DKUM: 15.01.2025; Views: 0; Downloads: 9
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10. Development and validation of the perceived deepfake trustworthiness questionnaire (PDTQ) in three languagesNejc Plohl, Izidor Mlakar, Letizia Aquilino, Piercosma Bisconti, Urška Smrke, 2025, original scientific article Abstract: Exposure to false information is becoming a common occurrence in our daily lives. New developments in artificial intelligence are now used to produce increasingly sophisticated multimedia false content, such as deepfakes, making false information even more challenging to detect and combat. This creates expansive opportunities to mislead individuals into believing fabricated claims and negatively influence their attitudes and behavior. Therefore, a better understanding of how individuals perceive such content and the variables related to the perceived trustworthiness of deepfakes is needed. In the present study, we developed and validated the Perceived Deepfake Trustworthiness Questionnaire (PDTQ) in English, Italian, and Slovene. This was done in three phases. First, we developed the initial pool of items by reviewing previous studies, generating items via interviews and surveys, and employing artificial intelligence. Second, we shortened and adapted the questionnaire according to experts’ evaluation of content validity and translated the questionnaire into Italian and Slovene. Lastly, we evaluated the psychometric characteristics via a cross-sectional study in three languages (N ¼ 733). The exploratory factor analyses suggested a two-factor solution, with the first factor measuring the perceived trustworthiness of the content and the second measuring the perceived trustworthiness of the presentation. This factorial structure was replicated in confirmatory factor analyses. Moreover, our analyses provided support for PDTQ’s reliability, measurement invariance across all three languages, and its construct and incremental validity. As such, the PDTQ is a reliable, measurement invariant, and valid tool for comprehensive exploration of individuals’ perception of deepfake videos. Keywords: deepfakes, misinformation, perception, questionnaire validation, trust Published in DKUM: 03.09.2024; Views: 30; Downloads: 46
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