1. Overview of the efficacy of using probiotics for neurosurgical and potential neurosurgical patientsSabina Fijan, Tomaž Šmigoc, 2024, review article Abstract: This review delves into the emerging field of the gut microbiota-brain axis, emphasizing its bidirectional communication and implications for neurological health, particularly in trauma and neurosurgery. While disruptions in this axis can lead to dysbiosis and hinder neurological recovery, recent studies have highlighted the therapeutic potential of interventions like probiotics in targeting this axis. This review aims to focus on the efficacy of probiotic supplementation to support the gut microbiota-brain axis in trauma, neurosurgery, or pain based on the current clinical trials to assess the complex interplays among probiotics, the gut microbiota, and the central nervous system (CNS). This comprehensive literature review identified 10 relevant publications on probiotic interventions for various neurosurgical conditions across multiple countries. These studies demonstrated diverse outcomes, with significant improvements observed in gastrointestinal mobility, inflammatory responses, and infection rates, particularly in post-traumatic brain injury and spinal surgery. Probiotics also showed promise in mitigating antibiotic-associated diarrhea and modulating inflammatory cytokines. Despite the promising findings, the complex interplays among probiotics, the gut microbiota, and the central nervous system (CNS) call for cautious interpretation. Conflicting outcomes emphasize the need for better-designed trials to understand strain-specific and disease-specific effects accurately. In conclusion, probiotics offer a promising adjuvant therapy for neurosurgical patients, traumatic brain injuries, and post-spinal surgery. However, further well-designed randomized controlled trials are essential to elucidate the intricate relationship between microbiome-modulating interventions and the CNS via the gut microbiota-brain axis.
Keywords: neurologic injury, neurosurgery, probiotics, synbiotics, microbiota, brain injury
Published in DKUM: 21.11.2024; Views: 0; Downloads: 6
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2. Učinki probiotikov pri bolečinah v križuNika Želimorski, 2024, undergraduate thesis Abstract: Probiotiki so živi mikroorganizmi, ki imajo pozitiven vpliv na zdravje gostitelja, kadar jih vnesemo v zadostni količini. Njihova uporaba prispeva k izboljšanju zdravja ljudi, vključno z vzdrževanjem imunskega sistema. Probiotični izdelki so priljubljena oblika namensko uporabljenih živil, ki koristijo zdravju. Temeljijo na mikroorganizmih, ki se pogosto naravno pojavljajo v črevesni mikrobioti ljudi in vzpostavljajo simbiotski odnos s svojim gostiteljem. Kljub številnim pozitivnim učinkom probiotikov na zdravje naš pregled literature ne prinaša pomembnega vpliva probiotikov na zmanjšanje bolečin v križu, kar kaže na potrebo po nadaljnjih raziskavah, ki bodo razjasnile vlogo specifičnih probiotičnih sevov, doziranja, trajanja terapije in drugih dejavnikov pri lajšanju bolečin v križu.
Keywords: probiotiki, bolečine v križu, preprečevanje bolečin, pacienti.
Published in DKUM: 23.10.2024; Views: 0; Downloads: 133
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4. Percutaneous trigeminal ganglion balloon compression rhizotomy: experience in 27 patientsTadej Strojnik, Tomaž Šmigoc, 2012, original scientific article Abstract: Purpose. Percutaneous ganglion balloon compression (PBC) is a minimally invasive procedure for treatment of trigeminal neuralgia. Materials and Methods. Twenty-seven (19 female and 8 male) patients, who presented with classical symptoms of trigeminal neuralgia, were included. Age ranged from34 to 91 years (median 62 years), 33 procedures were performed. Duration of the symptoms ranged from 1 year to 30 years (median 5 years). Results. After the procedure, pain relief was reported in 25 (93%) patients. In two patients, the pain remained the same. The pain free period ranged from 2 to 74 months (median 15 months). A mean duration of analgesia was longer in patients with ideal pear shape of balloon at the time of the procedure compared to nonideal shape (P = 0.01). No major complications occurred in our group of patients. Conclusions. Percutaneous trigeminal ganglion balloon compression is a safe, simple, and effective method for temporary pain relief in a selective group of trigeminal neuralgia patients.
Keywords: balloon compression
Published in DKUM: 15.06.2017; Views: 1150; Downloads: 490
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