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1.
Novel methacrylate-based multilayer nanofilms with incorporated FePt-based nanoparticles and the anticancer drug 5-fluorouracil for skin cancer treatment
Kristijan Skok, Tanja Zidarič, Kristjan Orthaber, Matevž Pristovnik, Nina Kostevšek, Kristina Žužek Rožman, Sašo Šturm, Lidija Gradišnik, Uroš Maver, Tina Maver, 2022, original scientific article

Abstract: Despite medical advances, skin-associated disorders continue to pose a unique challenge to physicians worldwide. Skin cancer is one of the most common forms of cancer, with more than one million new cases reported each year. Currently, surgical excision is its primary treatment; however, this can be impractical or even contradictory in certain situations. An interesting potential alternative could lie in topical treatment solutions. The goal of our study was to develop novel multilayer nanofilms consisting of a combination of polyhydroxyethyl methacrylate (PHEMA), polyhydroxypropyl methacrylate (PHPMA), sodium deoxycholate (NaDOC) with incorporated superparamagnetic iron–platinum nanoparticles (FePt NPs), and the potent anticancer drug (5-fluorouracil), for theranostic skin cancer treatment. All multilayer systems were prepared by spin-coating and characterised by atomic force microscopy, infrared spectroscopy, and contact angle measurement. The magnetic properties of the incorporated FePt NPs were evaluated using magnetisation measurement, while their size was determined using transmission electron microscopy (TEM). Drug release performance was tested in vitro, and formulation safety was evaluated on human-skin-derived fibroblasts. Finally, the efficacy for skin cancer treatment was tested on our own basal-cell carcinoma cell line.
Keywords: nanomaterials, bimodal therapy, topical skin treatmen, magnetic nanoparticles, thin films, skin cancer, methacrylates
Published in DKUM: 04.07.2024; Views: 43; Downloads: 10
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Multilayer methacrylate-based wound dressing as a therapeutic tool for targeted pain relief
Tanja Zidarič, Kristijan Skok, Kristjan Orthaber, Matevž Pristovnik, Lidija Gradišnik, Tina Maver, Uroš Maver, 2023, original scientific article

Abstract: This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief.
Keywords: wound dressings, pain relief, superparamagnetic nanoparticles, methacrylate
Published in DKUM: 19.04.2024; Views: 427; Downloads: 463
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The development of an electropolymerized, molecularly imprinted polymer (MIP) sensor for insulin determination using single-drop analysis
Tanja Zidarič, David Majer, Tina Maver, Matjaž Finšgar, Uroš Maver, 2023, original scientific article

Abstract: An electrochemical sensor for the detection of insulin in a single drop (50 μL) was developed based on the concept of molecularly imprinted polymers (MIP). The synthetic MIP receptors were assembled on a screen-printed carbon electrode (SPCE) by the electropolymerization of pyrrole (Py) in the presence of insulin (the protein template) using cyclic voltammetry. After electropolymerization, insulin was removed from the formed polypyrrole (Ppy) matrix to create imprinting cavities for the subsequent analysis of the insulin analyte in test samples. The surface characterization, before and after each electrosynthesis step of the MIP sensors, was performed using atomic force microscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The performance of the developed MIP–SPCE sensor was evaluated using a single drop of solution containing K3Fe(CN)6 and the square-wave voltammetry technique. The MIP–SPCE showed a linear concentration range of 20.0–70.0 pM (R2 = 0.9991), a limit of detection of 1.9 pM, and a limit of quantification of 6.2 pM. The rapid response time to the protein target and the portability of the developed sensor, which is considered a disposable MIP-based system, make this MIP–SPCE sensor a promising candidate for point-of-care applications. In addition, the MIP–SPCE sensor was successfully used to detect insulin in a pharmaceutical sample. The sensor was deemed to be accurate (the average recovery was 108.46%) and precise (the relative standard deviation was 7.23%).
Keywords: electrochemical sensors, electropolymerisation, electron microscopy
Published in DKUM: 14.03.2024; Views: 260; Downloads: 22
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Obvladovanje sladkorne bolezni s sodobnimi medicinsko tehničnimi pripomočki
Alen Markuš, 2023, master's thesis

Abstract: Uvod: Senzorji za merjenje glukoze v medceličnini, inzulinske črpalke s sistemom hibridne zaprte zanke in pametni inzulinski peresniki so pomemben tehnološki dosežek, ki je pripeljal do številnih koristi za bolnike, hkrati pa predstavlja nove izzive v različnih panogah, povezanih z iskanjem rešitev za boljše soočanje s sladkorno boleznijo. Senzorji omogočajo stalno spremljanje ravni glukoze v krvi, kar je izjemno pomembno za bolnike s sladkorno boleznijo, saj jim s tem omogočijo boljši nadzor in vodenje bolezni, posledično pa z dobro urejeno glikemijo živijo kakovostnejše življenje. Osredotočili smo se na stališča uporabnikove izkušnje, na drugi strani pa na pomen KMG za urejenost SB. Metode: Izvedli smo natančen pregled trga, kjer smo iskali sodobne in tehnološko napredne medicinsko-tehnične pripomočke za zdravljenje in obvladovanje sladkorne bolezni. Uporabili smo kvantitativno metodologijo raziskovanja ter validiran vprašalnik GME-Q kot orodje za oceno zadovoljstva. Rezultati: S pomočjo vprašalnika GME-Q za oceno zadovoljstva smo pridobili naslednje rezultate. Cronbachov koeficient alfa je znašal 0.919, kar odraža odlično notranjo konsistenco. Opravljena neodvisna analiza s pomočjo Cronbachovega koeficienta alfa je za vsako podlestvico znašala za učinkovitost 0.89, za priročnost 0.82 in za vsiljivost 0.757. Razprava in sklep: Rezultati naše analize kažejo, da so uporabniki zadovoljni s senzorji KMG v medceličnini. V Sloveniji je dostopnost senzorjev za KMG dobra, saj so na trgu prisotni trije proizvajalci in ima bolnik možnost izbire. Popolnoma drugačen je posnetek stanja na področju inzulinskih črpalk s sistemom hibridne zaprte zanke, saj je na trgu zgolj en proizvajalec. Pravi pametni inzulinski peresniki pa v Sloveniji sploh še niso prisotni. Tehnologija sodobnih medicinsko-tehničnih pripomočkov za zdravljenje sladkorne bolezni je pomemben tehnološki dosežek, ki se stalno nadgrajuje in izpopolnjuje, zato lahko na podlagi obstoječih raziskav trdimo, da so senzorji KMG pravi korak k izboljšanju vodenja sladkorne bolezni.
Keywords: sladkorna bolezen, management, kontinuirano merjenje glukoze, monitoring, e-zdravje, zadovoljstvo
Published in DKUM: 18.05.2023; Views: 796; Downloads: 132
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8.
The importance of the correct choice of Franz diffusion cell volume for in vitro drug release testing of wound dressings
Tina Maver, Uroš Maver, 2022, original scientific article

Keywords: in vitro drug release testing, Franz diffusion cells, simulation, naproxen, alginate
Published in DKUM: 16.02.2023; Views: 619; Downloads: 49
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9.
Določitev terapevtske koncentracije ekstrakta trpotca v 3D tiskanem nosilnem sistemu za optimalni učinek na rast kožnih celic : magistrsko delo
Klara Laura Konda, 2022, master's thesis

Abstract: V magistrskem delu smo podrobneje raziskali vpliv ekstraktov širokolistnega (Plantago major L.) in ozkolistnega (Plantago lanceolata L.) trpotca na rast kožnih celic. Ekstrakte obeh vrst trpotca smo ekstrahirali z različnimi topili in jih določili. V ekstraktih smo s tekočinsko kromatografijo visoke ločljivosti potrdili prisotnost avkubina, katalpola, verbaskozida in plantamajozida. Vsebnost celokupnih kemijskih spojin v ekstraktih smo določili s spektroskopskimi metodami ter njihovo antioksidativno delovanje z DPPH-metodo. Kinetiko sproščanja ekstraktov iz 3D-tiskanih obližev smo določili na podlagi in vitro testiranja sproščanja verbaskozida iz 3D-tiskanih obližev na avtomatiziranem sistemu Franzovih difuzijskih celic. Na podlagi dobljenih rezultatov ter rezultatov MTT-testa, pri katerem smo določili vpliv ekstraktov na viabilnost celic, smo v 3D-tiskane obliže vgradili metanolni ekstrakt širokolistnega trpotca ter etanolni ekstrakt ozkolistnega trpotca. V primeru obeh vrst trpotca smo določili optimalni masni delež, ki je znašal 0,50 % ekstrakta na maso 3D-tiskanega obliža. Relativna viabilnost je bila v primeru 3D-tiskanega obliža s širokolistnim trpotcem 1,39 in 1,49 v primeru ekstrakta ozkolistnega trpotca. Z MTT-testom smo tako dokazali biokompatibilnost vgrajenih ekstraktov ter njihov spodbujevalni vpliv na viabilnost in proliferacijo fibroblastov. Z analizo površine 3D-tiskanih obližev z ali brez vgrajenega ekstrakta trpotca, ki smo jo naredili z vrstičnim elektronskim mikroskopom, smo potrdili vpliv ekstraktov na spremembo morfologije obližev. S testom degradacije in testom navzemanja vlage smo pokazali, da so obliži biorazgradljivi in da imajo ustrezen profil nabrekanja ter tako potrdili njihov potencialni terapevtski učinek in uporabo za celjenje ran.
Keywords: širokolistni trpotec, ozkolistni trpotec, aktivne učinkovine, 3D-tiskan nosilni sistem, terapevtska koncentracija, rast kožnih celic
Published in DKUM: 03.11.2022; Views: 580; Downloads: 148
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10.
Analiza prevlek, pripravljenih na osnovi elektropredenja in 3D-tiskanja
Mihela Mihelič, 2020, master's thesis

Abstract: Namen magistrske naloge je predstaviti postopek oblaganja na nosilca iz nerjavnega medicinskega jekla AISI 316LVM in na zlitino Ti90Al6V4, kot modelov za kolčne proteze. Z uporabo dveh naprednih tehnik na področju biomedicinskega inženirstva, elektropredenjem in 3D-tiskanjem, smo funkcionalizirali nosilce z biokompatibilnimi prevlekami z vgrajeno zdravilno učinkovino (ZU) klindamicin.
Keywords: klindamicin, elektropredenje, 3D-tiskanje, kolčne proteze, biokompatibilnost
Published in DKUM: 09.06.2020; Views: 1082; Downloads: 138
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