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Abstract: Background: Two prospective randomized studies analysing cutaneous melanoma (CM) patients with sentinel lymph node (SLN) metastases and rapid development of systemic adjuvant therapy have changed our approach to stage III CM treatment. The aim of this study was to compare results of retrospective survival analysis of stage III CM patients% treatment from Slovenian national CM register to leading international clinical guidelines. Patients and methods: Since 2000, all Slovenian CM patients with primary tumour % TIb are treated at the Institute of Oncology Ljubljana and data are prospectively collected into a national CM registry. A retrospective analysis of 2426 sentinel lymph node (SLN) biopsies and 789 lymphadenectomies performed until 2015 was conducted using Kaplan-Meier survival curves and log-rank tests. Results: Positive SLN was found in 519/2426 (21.4%) of patients and completion dissection (CLND) was performed in 455 patients. The 5-year overall survival (OS) of CLND group was 58% vs. 47% of metachronous metastases group (MLNM) (p = 0.003). The 5-year OS of patients with lymph node (LN) metastases and unknown primary site (UPM) was 45% vs. 21% of patients with synchronous LN metastasis. Patients with SLN tumour burden < 0.3 mm had 5-year OS similar to SLN negative patients (86% vs. 85%; p = 0.926). The 5-year OS of patients with burden > 1.0 mm was similar to the MLNM group (49% vs. 47%; p = 0.280). Conclusions: Stage III melanoma patients is a heterogeneous group with significant OS differences. CLND after positive SLNB might still remain a method of treatment for selected patients with stage III.
Keywords: cutaneous melanoma, surgery treatment, sentinel node biopsy, completion lymph node dissection, overall surviva
Published in DKUM: 08.10.2024; Views: 0; Downloads: 2
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Abstract: Požarna varnost ima v objektih kritične infrastrukture pomembno vlogo predvsem v skladiščih naftnih derivatov, kjer obstaja veliko tveganje za požare in eksplozije. Skladiščenje naftnih derivatov predstavlja specifično nevarnost za okolje ter vse udeležence, ki so povezani z njimi. Najpogostejši vzroki za požare so operativne napake in napake pri vzdrževanju. Požari lahko povzročijo veliko okoljsko škodo, kot so onesnaženje zraka, tal in vode, ter dolgoročno vplivajo na zdravje prebivalcev in lokalne skupnosti. Smernice za preprečevanje in obvladovanje izrednih dogodkov zajemajo izvajanje varnostnih ukrepov za preprečevanje in obvladovanje nesreč. Uporaba sistemov za zaznavanje in avtomatsko gašenje požarov znatno izboljšata varnost. Nadgradnja sistemov za nadzor in avtomatizacijo procesov zmanjšuje človeške napake in povečuje učinkovitost. Skladišča uporabljajo napredne varnostne sisteme za zmanjšanje tveganja okoljske škode. Kljub varnostnim ukrepom lahko pride do potencialnih okoljskih škod, saj požari in izlitja lahko povzročijo obsežno ekološko škodo. Področje požarne varnosti je marsikje pomanjkljivo, kar lahko vodi do nejasnosti pri izvajanju varnostnih ukrepov. Raziskava izpostavlja omejen dostop do nekaterih pomembnih informacij, kar ovira celovito analizo varnosti. V določenih primerih je infrastruktura za gašenje požarov in varnostnih naprav zastarela ali neustrezno vzdrževana. Zagotavljanje požarne varnosti v skladiščih naftnih derivatov zahteva stalno posodabljanje varnostnih praks in tesno sodelovanje med institucijami in obrati. Le tako je mogoče učinkovito zmanjšati tveganja in zaščititi ljudi, okolje ter kritično infrastrukturo.
Keywords: požarna varnost, kritična infrastruktura, naftni derivati, diplomske naloge
Published in DKUM: 27.09.2024; Views: 0; Downloads: 22
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Abstract: For successful dosing of plant protection products, the characteristics of the vine canopies should be known, based on which the spray amount should be dosed. In the field experiment, we compared two optical experimental methods, terrestrial lidar and aerial photogrammetry, with manual defoliation of some selected vines. Like those of other authors, our results show that both terrestrial lidar and aerial photogrammetry were able to represent the canopy well with correlation coefficients around 0.9 between the measured variables and the number of leaves. We found that in the case of aerial photogrammetry, significantly more points were found in the point cloud, but this depended on the choice of the ground sampling distance. Our results show that in the case of aerial UAS photogrammetry, subdividing the vine canopy segments to 5 × 5 cm gives the best representation of the volume of vine canopies.
Keywords: precision agriculture, remote sensing, 3D point clouds, vineyard, canopy reconstruction, terrestrial lidar, aerial photogrammetry, manual defoliation
Published in DKUM: 15.07.2024; Views: 123; Downloads: 10
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Abstract: Background and Objectives: Increased revision rate of dual-modular (DM) femoral stems in primary total hip arthroplasty (THA) because of modular-neck breakage and adverse local tissue reactions (ALTRs) to additional junction damage products is well established and some designs have been recalled from the market. However, some long-term studies of specific DM stems did not confirm the inferiority of these stems compared to standard single-modular (SM) stems, and a head-to-head comparison THA is missing. The objectives of this multicentre study were to determine the survivorship and complication rates of a common DM stem design compared to a similar SM stem. Materials and Methods: In a time frame from January 2012 to November 2015, a cohort of 807 patients (882 hips) consecutively underwent primary cementless THAs at two orthopaedic centres. 377 hips were treated with a Zweimüller-type DM stem THA system and 505 hips with a similar SM stem THA system, both including a modern press-fit acetabulum. Kaplan-Meier survivorship and complication rates were compared between both groups in a median follow-up of 9.0 years (maximum, 9.9 years). Results: The 9-year survivorship of the DM stem THA system (92.6%, 95% CI 89.9–95.3) was significantly lower than that of the SM stem THA system (97.0%, 95% CI 95.2–98.8). There were no differences in revision rates for septic loosening, dislocation, and periprosthetic fractures between the two groups. One ceramic inlay and one Ti-alloy modular neck breakage occurred in the DM stem THA system group, but the main reason for revision in this group was aseptic loosening of components. Conclusions: The survivorship of the DM stem THA system was lower than the similar SM stem THA system in a comparable clinical environment with long-term follow-up. Our results confirmed that no rationale for stem modularity exists in primary THAs.
Keywords: total hip arthroplasty, modular necks, exchangeable necks, survival rate, complications, revision rate, primary hip replacement, prosthesis, Ti-alloy
Published in DKUM: 18.03.2024; Views: 320; Downloads: 5
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Abstract: The purpose of the study is to examinewhether two differentwork commitment profiles influence service quality in the hospitality sector in Slovenia and Serbia and how the implications of the differences can be used in the tourism and hospitality industry. Combining a qualitative and quantitative approach, two new instruments were developed for this study. The first instrumentwas created on the basis of short, structured interviews with employees. Two factors explaining the two different commitment profiles were determined with statistical analysis and with themethod of clustering, four dimensions of commitment profiles formingwere extracted. The second instrument was developed on the basis of existing evaluation forms for employees in the tourism industry and interviews with leading and middle managers of hotels. The findings of the study show that there is a small proportion of professionallyoriented employees in the tourism sector, and the difference among employees is evident in the ranking of working values. These results could be useful formanagers in planning and organising their human resources and also in planning further development of their companies% human resource policies. The original contribution of the article is the ranking of working values and the perception of quality work by employees in the hospitality sector. The study also reveals new evidence on different types of commitment profiles.
Keywords: tourism, hospitality, organisational commitment, professional commitment, human resources management, HRM
Published in DKUM: 29.01.2024; Views: 270; Downloads: 19
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