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1.
Povezanost med empatijo staršev in empatijo njihovega otroka : diplomsko delo
Kristina Cvitkovič, 2023, undergraduate thesis

Abstract: Namen diplomskega dela je bil raziskati povezanost med empatijo staršev in empatijo njihovega otroka ter ugotoviti, kako je empatija med starši in otrokom povezana. Zanimalo nas je, ali obstajajo pomembne razlike v empatiji med dečki in deklicami v obdobju zgodnjega otroštva glede na starost. Raziskavo smo opravili s pomočjo Testa empatije (Baron-Cohen in Wheelwright, 2004). Sodelovalo je 105 staršev in njihovi predšolski otroci. Pridobljene podatke smo obdelali s programom Microsoft Excel in programom IBM SPSS Statistics. Rezultati testa empatije so pokazali, da obstaja pomembna povezanost med empatijo staršev in empatijo njihovih otrok, da je spol otroka povezan s stopnjo empatije in da se stopnja empatije s starostjo otrok ne spreminja. V razlagi rezultatov smo poudarili, da je stopnja empatije povezana s spoznavnim in miselnim razvojem otroka in da je tako dobro, da vzgojitelji poznajo otrokove socialne možnosti.
Keywords: empatija, predšolski otrok, starši, test empatije, Simon Baron-Cohen, Sally Wheelwright
Published in DKUM: 19.10.2023; Views: 298; Downloads: 38
.pdf Full text (581,99 KB)

2.
Determination of topiramate in human plasma using liquid chromatography tandem mass spectrometry
Tanja Vnučec, Lea Cvitkovič-Maričič, Helena Prosen, Darinka Brodnjak-Vončina, 2013, original scientific article

Abstract: The LC-MS/MS method for determination of the anti-epileptic drug topiramate (TPM) in human plasma was developed and validated for pharmacokinetic and bioequivalence study purposes. For quantitative determination of TPM values the method with deuterated internal standard (topiramate-d12) and liquid chromatography with tandem mass spectrometry was used. TPM was extracted from the human plasma using the solid-phase extraction procedure on a Strata X extraction column. Negative ions were monitored in the selected reaction monitoring mode (SRM) and transitions m/z 338.2 > 78.2 and m/z 350.3 > 78.2 were used for the quantitative evaluation of TPM and the internal standard, respectively. The results obtained from validation were statistically evaluated according to the requirements of European Medicines Agency (EMA) and Food and Drug Administration (FDA) regulatory guidelines. The linearity of the method was checked within a concentration range from 10 to 2000 ng/mL. Successful validation confirmed that this method is precise, accurate, sensitive and therefore suitable for determination of topiramate plasma levels in pharmacokinetic and bioequivalence studies.
Keywords: topiramate, liquid chromatography tandem mass spectroscopy, human plasma, bioequivalence study
Published in DKUM: 18.08.2017; Views: 1457; Downloads: 96
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3.
Determination of candesartan in human plasma with liquid chromatography - tandem mass spectrometry
Vanja Forjan, Lea Cvitkovič-Maričič, Helena Prosen, Darinka Brodnjak-Vončina, 2016, original scientific article

Abstract: A sensitive, specific and rapid liquid chromatography - tandem mass spectrometry method was developed and validated for the determination of candesartan in human plasma. Analyte was separated from endogenous components present in plasma by solid phase extraction. Chromatographic separation was performed on Gemini C18 analytical column using mobile phase acetonitrile – 5 mM ammonium formate pH 2 (90:10, v/v) at flow rate of 0.3 mL/min. For detection, tandem mass spectrometry in SRM mode with positive electrospray ionization was used. The mass transitions m/z 441.1 > 263.1 and 445.1 > 267.1 were used to determine candesartan by using candesartan-d4 as an internal standard. After development, the method was validated according to the requirements of EMA regulatory guidelines in the concentration range 1 - 400 ng/ml in human plasma. Limit of quantification (LLOQ) was 1 ng/ml. The developed and validated method proved to be very fast and reproducible and was therefore successfully implemented in pharmacokinetic and bioequivalence studies with large number of study samples.
Keywords: candesartan, liquid chromatography, tandem mass spectrometry, human plasma
Published in DKUM: 17.08.2017; Views: 1417; Downloads: 380
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