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Abstract: In this study, a novel biodegradable poly(lactic-co-glycolic) acid coating containing a model anti-inflammatory drug (ketoprofen) was prepared on TiAl6V4 substrate for use in orthopedic medicine by a two-step process combining drop casting and supercritical CO2-assisted foaming. The prepared coating was first investigated by surface analysis techniques using time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy. The combined results confirmed the loading of ketoprofen and its homogeneous spatial distribution in the coating. 3D profilometry revealed increased surface roughness of the coating compared to the bare TiAl6V4 substrate, which is favorable for cell adhesion. Furthermore, the electrochemical measurements (i.e., electrochemical impedance spectroscopy and potentiodynamic curve measurements) demonstrated that the coating application significantly mitigated corrosion compared to the bare TiAl6V4 substrate. In vitro drug release tests revealed extended drug release in simulated body fluids with zero-order release kinetics. Finally, the promising cell testing results using adipose-derived mesenchymal stem cells and osteoblasts confirmed the applicability of the coating for implants. Overall, the results of this study highlight the significant potential of the developed bioactive coating for future orthopedic applications.
Keywords: TiAlV, bioactive coating, implants, PLGA, supercritical foaming, ketoprofen
Published in DKUM: 14.03.2025; Views: 0; Downloads: 8
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Abstract: The electroanalytical and surface characterization of copper immersed in 3 wt.% NaCl solution containing 1 mM of 2-phenylimidazole (2PhI) is presented. It was proven that 2PhI can be employed as corrosion inhibitor for copper using various electrochemical analyses, such as cyclic voltammetry, chronopotentiometry, electrochemical impedance spectroscopy, and potentiodynamic curve measurements. The adsorption of 2PhI on copper was further analyzed by 3D-profilometry, attenuated total reflectance Fourier transform infrared spectroscopy, contact angle measurements, and scanning electron microscopy equipped with an energy dispersive X-ray spectrometer. This system was therefore comprehensively described by various analytical approaches.
Keywords: corrosion inhibitor, copper, electrochemical impedance spectroscopy, EIS, cyclic voltammetry, attenuated total reflectance Fourier transform infrared, ATR-FTIR
Published in DKUM: 17.01.2019; Views: 2084; Downloads: 401
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