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1.
Radiotherapy department supported by an optimization algorithm for scheduling patient appointments
Marcela Chavez, Silvia Gonzalez, Ruiz Alvaro, Duflot Patrick, Nicolas Jansen, Izidor Mlakar, Umut Arioz, Valentino Šafran, Philippe Kolh, Van Gasteren Marteyn, 2025, original scientific article

Abstract: Prompt administration of radiotherapy (RT) is one of the most effective treatments against cancer. Eachday, the radiotherapy departments of large hospitals must plan numerous irradiation sessions, con-sidering the availability of human and material resources, such as healthcare professionals and linearaccelerators. With the increasing number of patients suffering from different types of cancers, manuallyestablishing schedules following each patient’s treatment protocols has become an extremely difficultand time-consuming task. We propose an optimization algorithm that automatically schedules andgenerates patient appointments. The model can rearrange fixed appointments to accommodate urgentcases, enabling hospitals to schedule appointments more efficiently. It respects the different treatment Prompt administration of radiotherapy (RT) is one of the most effective treatments against cancer. Eachday, the radiotherapy departments of large hospitals must plan numerous irradiation sessions, con-sidering the availability of human and material resources, such as healthcare professionals and linearaccelerators. With the increasing number of patients suffering from different types of cancers, manuallyestablishing schedules following each patient’s treatment protocols has become an extremely difficultand time-consuming task. We propose an optimization algorithm that automatically schedules andgenerates patient appointments. The model can rearrange fixed appointments to accommodate urgentcases, enabling hospitals to schedule appointments more efficiently. It respects the different treatment.
Keywords: appointments, hospital management, optimization algorithm, patient satisfaction, planning, radiotherapy
Published in DKUM: 25.02.2025; Views: 0; Downloads: 7
.pdf Full text (1,19 MB)

2.
Exploring the feasibility of generative AI in persona research : a omparative analysis of large language model-generated and human-crafted personas in obesity research
Urška Smrke, Ana Rehberger, Nejc Plohl, Izidor Mlakar, 2025, original scientific article

Abstract: This study investigates the perceptions of Persona descriptions generated using three different large language models (LLMs) and qualitatively developed Personas by an expert panel involved in obesity research. Six different Personas were defined, three from the clinical domain and three from the educational domain. The descriptions of Personas were generated using qualitative methods and the LLMs (i.e., Bard, Llama, and ChatGPT). The perception of the developed Personas was evaluated by experts in the respective fields. The results show that, in general, the perception of Personas did not significantly differ between those generated using LLMs and those qualitatively developed by human experts. This indicates that LLMs have the potential to generate a consistent and valid representation of human stakeholders. The LLM-generated Personas were perceived as believable, relatable, and informative. However, post-hoc comparisons revealed some differences, with descriptions generated using the Bard model being in several Persona descriptions that were evaluated most favorably in terms of empathy, likability, and clarity. This study contributes to the understanding of the potential and challenges of LLM-generated Personas. Although the study focuses on obesity research, it highlights the importance of considering the specific context and the potential issues that researchers should be aware of when using generative AI for generating Personas.
Keywords: user personas, obesity, large language models, value sensitive design, digital health interventions
Published in DKUM: 14.02.2025; Views: 0; Downloads: 4
.pdf Full text (812,18 KB)

3.
Decoding anxiety : a scoping review of observable cues
Urška Smrke, Izidor Mlakar, Ana Rehberger, Leon Žužek, Nejc Plohl, 2024, review article

Abstract: Background: While anxiety disorders are one of the most prevalent mental diseases, they are often overlooked due to shortcomings of the existing diagnostic procedures, which predominantly rely on self-reporting. Due to recent technological advances, this source of information could be complemented by the so-called observable cues – indicators that are displayed spontaneously through individuals’ physiological responses or behaviour and can be detected by modern devices. However, while there are several individual studies on such cues, this research area lacks a synthesis. In line with this, our scoping review aimed to identify observable cues that offer meaningful insight into individuals’ anxiety and to determine how these cues can be measured. Methods: We followed the PRISMA guidelines for scoping reviews. The search string containing terms related to anxiety and observable cues was entered into four databases (Web of Science, MEDLINE, ERIC, IEEE). While the search – limited to English peer-reviewed records published from 2012 onwards – initially yielded 2311 records, only 33 articles fit our selection criteria and were included in the final synthesis. Results: The scoping review unravelled various categories of observable cues of anxiety, specifically those related to facial expressions, speech and language, breathing, skin, heart, cognitive control, sleep, activity and motion, location data and smartphone use. Moreover, we identified various approaches for measuring these cues, including wearable devices, and analysing smartphone usage and social media activity. Conclusions: Our scoping review points to several physiological and behavioural cues associated with anxiety and highlights how these can be measured. These novel insights may be helpful for healthcare practitioners and fuel future research and technology development. However, as many cues were investigated only in a single study, more evidence is needed to generalise these findings and implement them into practice with greater confidence.
Keywords: anxiety, observable cues, digital biomarkers, scoping review, physiological cues, behavioural cues
Published in DKUM: 07.02.2025; Views: 0; Downloads: 4
.pdf Full text (910,98 KB)

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An end-to-end framework for extracting observable cues of depression from diary recordings
Izidor Mlakar, Umut Arioz, Urška Smrke, Nejc Plohl, Valentino Šafran, Matej Rojc, 2024, original scientific article

Abstract: Because of the prevalence of depression, its often-chronic course, relapse and associated disability, early detection and non-intrusive monitoring is a crucial tool for timely diagnosis and treatment, remission of depression and prevention of relapse. In this way, its impact on quality of life and well-being can be limited. Current attempts to use artificial intelligence for the early classification of depression are mostly data-driven and thus non-transparent and lack effective means to deal with uncertainties. Therefore, in this paper, we propose an end-to-end framework for extracting observable depression cues from diary recordings. Furthermore, we also explore its feasibility for automatic detection of depression symptoms using observable behavioural cues. The proposed end-to-end framework for extracting depression was used to evaluate 28 video recordings from the Symptom Media dataset and 27 recordings from the DAIC-WOZ dataset. We compared the presence of the extracted features between recordings of individuals with and without a depressive disorder. We identified several cues consistent with previous studies in terms of their differentiation between individuals with and without depressive disorder across both datasets among language (i.e., use of negatively valanced words, use of first-person singular pronouns, some features of language complexity, explicit mentions of treatment for depression), speech (i.e., monotonous speech, voiced speech and pauses, speaking rate, low articulation rate), and facial cues (i.e., rotational energy of head movements). The nature/context of the discourse, the impact of other disorders and physical/psychological stress, and the quality and resolution of the recordings all play an important role in matching the digital features to the relevant background. In this way, the work presented in this paper provides a novel approach to extracting a wide range of cues relevant to the classification of depression and opens up new opportunities for further research.
Keywords: digital biomarkers of depression, facial cues, speech cues, language cues, deep learning, end-to-end pipeline, artificial intelligence
Published in DKUM: 17.01.2025; Views: 0; Downloads: 3
.pdf Full text (2,34 MB)

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Development and validation of the perceived deepfake trustworthiness questionnaire (PDTQ) in three languages
Nejc Plohl, Izidor Mlakar, Letizia Aquilino, Piercosma Bisconti, Urška Smrke, 2024, original scientific article

Abstract: Exposure to false information is becoming a common occurrence in our daily lives. New developments in artificial intelligence are now used to produce increasingly sophisticated multimedia false content, such as deepfakes, making false information even more challenging to detect and combat. This creates expansive opportunities to mislead individuals into believing fabricated claims and negatively influence their attitudes and behavior. Therefore, a better understanding of how individuals perceive such content and the variables related to the perceived trustworthiness of deepfakes is needed. In the present study, we developed and validated the Perceived Deepfake Trustworthiness Questionnaire (PDTQ) in English, Italian, and Slovene. This was done in three phases. First, we developed the initial pool of items by reviewing previous studies, generating items via interviews and surveys, and employing artificial intelligence. Second, we shortened and adapted the questionnaire according to experts’ evaluation of content validity and translated the questionnaire into Italian and Slovene. Lastly, we evaluated the psychometric characteristics via a cross-sectional study in three languages (N ¼ 733). The exploratory factor analyses suggested a two-factor solution, with the first factor measuring the perceived trustworthiness of the content and the second measuring the perceived trustworthiness of the presentation. This factorial structure was replicated in confirmatory factor analyses. Moreover, our analyses provided support for PDTQ’s reliability, measurement invariance across all three languages, and its construct and incremental validity. As such, the PDTQ is a reliable, measurement invariant, and valid tool for comprehensive exploration of individuals’ perception of deepfake videos.
Keywords: deepfakes, misinformation, perception, questionnaire validation, trust
Published in DKUM: 03.09.2024; Views: 30; Downloads: 11
.pdf Full text (2,12 MB)
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8.
Multilingual framework for risk assessment and symptom tracking (MRAST)
Valentino Šafran, Simon Lin, Jama Nateqi, Alistair G. Martin, Urška Smrke, Umut Arioz, Nejc Plohl, Matej Rojc, Dina Běma, Marcela Chavez, Matej Horvat, Izidor Mlakar, 2024, original scientific article

Abstract: The importance and value of real-world data in healthcare cannot be overstated because it offers a valuable source of insights into patient experiences. Traditional patient-reported experience and outcomes measures (PREMs/PROMs) often fall short in addressing the complexities of these experiences due to subjectivity and their inability to precisely target the questions asked. In contrast, diary recordings offer a promising solution. They can provide a comprehensive picture of psychological well-being, encompassing both psychological and physiological symptoms. This study explores how using advanced digital technologies, i.e., automatic speech recognition and natural language processing, can efficiently capture patient insights in oncology settings. We introduce the MRAST framework, a simplified way to collect, structure, and understand patient data using questionnaires and diary recordings. The framework was validated in a prospective study with 81 colorectal and 85 breast cancer survivors, of whom 37 were male and 129 were female. Overall, the patients evaluated the solution as well made; they found it easy to use and integrate into their daily routine. The majority (75.3%) of the cancer survivors participating in the study were willing to engage in health monitoring activities using digital wearable devices daily for an extended period. Throughout the study, there was a noticeable increase in the number of participants who perceived the system as having excellent usability. Despite some negative feedback, 44.44% of patients still rated the app’s usability as above satisfactory (i.e., 7.9 on 1–10 scale) and the experience with diary recording as above satisfactory (i.e., 7.0 on 1–10 scale). Overall, these findings also underscore the significance of user testing and continuous improvement in enhancing the usability and user acceptance of solutions like the MRAST framework. Overall, the automated extraction of information from diaries represents a pivotal step toward a more patient-centered approach, where healthcare decisions are based on real-world experiences and tailored to individual needs. The potential usefulness of such data is enormous, as it enables better measurement of everyday experiences and opens new avenues for patient-centered care.
Keywords: multilingual framework, risk assessment, symptom tracking, chronic diseases, patient-centered care, real-world data
Published in DKUM: 12.08.2024; Views: 74; Downloads: 13
.pdf Full text (5,29 MB)

9.
Using structural equation modeling to explore patients’ and healthcare professionals’ expectations and attitudes towards socially assistive humanoid robots in nursing and care routine
Izidor Mlakar, Urška Smrke, Vojko Flis, Nina Kobilica, Samo Horvat, Bojan Ilijevec, Bojan Musil, Nejc Plohl, 2023, original scientific article

Abstract: Healthcare systems around the world are currently witnessing various challenges, including population aging and workforce shortages. As a result, the existing, overworked staff are struggling to meet the ever-increasing demands and provide the desired quality of care. One of the promising technological solutions that could complement the human workforce and alleviate some of their workload, are socially assistive humanoid robots. However, despite their potential, the implementation of socially assistive humanoid robots is often challenging due to low acceptance among key stakeholders, namely, patients and healthcare professionals. Hence, the present study first investigated the extent to which these stakeholders accept the use of socially assistive humanoid robots in nursing and care routine, and second, explored the characteristics that contribute to higher/lower acceptance within these groups, with a particular emphasis on demographic variables, technology expectations, ethical acceptability, and negative attitudes. In study 1, conducted on a sample of 490 healthcare professionals, the results of structural equation modeling showed that acceptance is driven primarily by aspects of ethical acceptability, although education and technology expectations also exert an indirect effect. In study 2, conducted on a sample of 371 patients, expectations regarding capabilities and attitudes towards the social influence of robots emerged as important predictors of acceptance. Moreover, although acceptance rates differed between tasks, both studies show a relatively high acceptance of socially assistive humanoid robots. Despite certain limitations, the study findings provide essential knowledge that enhances our understanding of stakeholders’ perceptions and acceptance of socially assistive humanoid robots in hospital environments, and may guide their deployment.
Keywords: socially assistive humanoid robots, attitudes, expectations, patients, healthcare professionals
Published in DKUM: 12.06.2024; Views: 166; Downloads: 15
.pdf Full text (1,74 MB)
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10.
Measuring young individuals’ responses to climate change : validation of the Slovenian versions of the climate anxiety scale and the climate change worry
Nejc Plohl, Izidor Mlakar, Bojan Musil, Urška Smrke, 2023, original scientific article

Abstract: Introduction: While increasing awareness of climate change is needed to address this threat to the natural environment and humanity, it may simultaneously negatively impact mental health. Previous studies suggest that climate-specific mental health phenomena, such as climate anxiety and worry, tend to be especially pronounced in youth. To properly understand and address these issues, we need valid measures that can also be used in non-Anglophone samples. Therefore, in the present paper, we aimed to validate Slovenian versions of the Climate Anxiety Scale (CAS) and the Climate Change Worry Scale (CCWS) among Slovenian youth. Method: We conducted an online survey in which 442 young individuals (18–24 years) from Slovenia filled out the two central questionnaires and additional instruments capturing other relevant constructs (e.g., general anxiety, neuroticism, and behavioral engagement). Results: The confirmatory factor analyses results supported the hypothesized factorial structure of the CAS (two factors) and the CCWS (one factor). Both scales also demonstrated great internal reliability. Moreover, the analyses exploring both constructs’ nomological networks showed moderate positive associations with similar measures, such as anxiety and stress (convergent validity), and very weak associations with measures they should not be particularly related to, such as narcissism (discriminant validity). Lastly, we found that the CAS and, even more so, the CCWS have unique predictive value in explaining outcomes such as perceived threat, support for climate policies, and behavioral engagement (incremental validity). Discussion: Overall, Slovenian versions of the CAS and the CCWS seem to be valid, reliable, and appropriate for future studies tackling young individuals’ responses to climate change. Limitations of the study and areas for future research are discussed.
Keywords: climate anxiety, climate change, climate worry, validation, youth
Published in DKUM: 04.06.2024; Views: 137; Downloads: 28
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