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Abstract: This study investigates the impact of integrating autonomous mobile robots (AMRs) into order picking, with a particular focus on how age influence human performance. Our research employs a multimethod approach, combining descriptive statistics, ANOVA, and post-experiment survey data analysis to evaluate the effects of AMR-assisted picking compared to manual cart picking. The results demonstrate that AMRs significantly reduce order-picking times (OPTs) and variability in performance across both age groups, with the older group showing an OPT improvement of 23.68%, and the younger group 29.40%. The ANOVA revealed that age significantly influenced OPTs. Additionally, the survey data indicated that participants perceived AMRs as simple to use and collaborative, with a strong positive correlation between AMR positioning and collaboration experience. These findings highlight the benefits of AMRs in enhancing efficiency and consistency in warehouse operations. The study underscores the importance of considering human factors in the design and implementation of robotic systems, paving the way for a human-centric Industry 5.0. Future research should attempt to achieve empirical data from real industrial operations, with the focus on larger sample sizes and the long-term effects of AMR integration on job satisfaction and overall performance.
Keywords: order picking, aging, autonomous mobile robots, experimental study
Published in DKUM: 27.03.2025; Views: 0; Downloads: 1
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Abstract: Within the islets of Langerhans, beta cells orchestrate synchronized insulin secretion, a pivotal aspect of metabolic homeostasis. Despite the inherent heterogeneity and multimodal activity of individual cells, intercellular coupling acts as a homogenizing force, enabling coordinated responses through the propagation of intercellular waves. Disruptions in this coordination are implicated in irregular insulin secretion, a hallmark of diabetes. Recently, innovative approaches, such as integrating multicellular calcium imaging with network analysis, have emerged for a quantitative assessment of the cellular activity in islets. However, different groups use distinct experimental preparations, microscopic techniques, apply different methods to process the measured signals and use various methods to derive functional connectivity patterns. This makes comparisons between findings and their integration into a bigger picture difficult and has led to disputes in functional connectivity interpretations. To address these issues, we present here a systematic analysis of how different approaches influence the network representation of islet activity. Our findings show that the choice of methods used to construct networks is not crucial, although care is needed when combining data from different islets. Conversely, the conclusions drawn from network analysis can be heavily affected by the pre-processing of the time series, the type of the oscillatory component in the signals, and by the experimental preparation. Our tutorial-like investigation aims to resolve interpretational issues, reconcile conflicting views, advance functional implications, and encourage researchers to adopt connectivity analysis. As we conclude, we outline challenges for future research, emphasizing the broader applicability of our conclusions to other tissues exhibiting complex multicellular dynamics.
Keywords: islets of Langerhans, beta cells, calcium signaling, intercellular communication, functional networks, myosin model
Published in DKUM: 09.12.2024; Views: 0; Downloads: 4
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Abstract: Rapid and reliable immunosensing is undoubtedly one of the priorities in the efficient management and combat against a pandemic, as society has experienced with the SARS-CoV-2 outbreak; simple and cost-effective sensing strategies are at the forefront of these efforts. In this regard, 2D-layered MXenes hold great potential for electrochemical biosensing due to their attractive physicochemical properties. Herein, we present a V$_2$CT$_x$ MXene-based sensing layer as an integral part of a label-free immunosensor for sensitive and selective detection of the SARS-CoV-2 spike protein. The sensor was fabricated on a supporting screen-printed carbon electrode using Nafion as an immobilizing agent for MXene and glutaraldehyde, the latter enabling effective binding of protein A for further site-oriented immobilization of anti-SARS-CoV-2 antibodies. A thorough structural analysis of the sensor architecture was carried out, and several key parameters affecting the fabrication and analytical performance of the immunosensor were investigated and optimized. The immunosensor showed excellent electroanalytical performance in combination with an impedimetric approach and exhibited a low detection limit of only 45 fM SARS-CoV-2 spike protein. Its practical applicability was successfully demonstrated by measuring the spike protein in a spiked artificial nasopharyngeal fluid sample.
Keywords: imunosenzorji, polprevodniške nanostrukture, proteini, spike protein, immunosensors, SARS-CoV-2, V2CTxMXene
Published in DKUM: 29.08.2024; Views: 42; Downloads: 4
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Keywords: resource reclamation, single cell protein, electrodialysis, forward osmosis, Saccharomyces cerevisiae
Published in DKUM: 10.05.2024; Views: 180; Downloads: 20
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Abstract: We argue that global F-theory compactifications to four dimensions gener- ally exhibit higher rank Yukawa matrices from multiple geometric contributions known as Yukawa points. The holomorphic couplings furthermore have large hierarchies for generic complex structure moduli. Unlike local considerations, the compact setup realizes these features all through geometry, and requires no instanton corrections. As an example, we consider a concrete toy model with SU(5) x U(1) gauge symmetry. From the geometry, we find two Yukawa points for the 10-25-4 coupling, producing a rank two Yukawa matrix. Our methods allow us to track all complex structure dependencies of the holomorphic couplings and study the ratio numerically. This reveals hierarchies of O(10(5)) and larger on a full-dimensional subspace of the moduli space.
Keywords: F-theory, supersymmetric effective theories
Published in DKUM: 16.10.2023; Views: 262; Downloads: 21
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