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Naslov:Bioactive functional nanolayers of chitosan-lysine surfactant with single- and mixed-protein-repellent and antibiofilm properties for medical implants
Avtorji:ID Ajdnik, Urban (Avtor)
ID Fras Zemljič, Lidija (Avtor)
ID Plohl, Olivija (Avtor)
ID Pérez, Lourdes (Avtor)
ID Trček, Janja (Avtor)
ID Bračič, Matej (Avtor)
ID Mohan, Tamilselvan (Avtor)
Datoteke:.pdf ajdnik-et-al-2021-bioactive-functional-nanolayers-of-chitosan-lysine-surfactant-with-single-and-mixed-protein-repellent.pdf (4,24 MB)
MD5: AB33C47B2993FC98239EDF17508702AC
 
URL https://pubs.acs.org/doi/10.1021/acsami.1c01993#
 
Jezik:Angleški jezik
Vrsta gradiva:Neznano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FS - Fakulteta za strojništvo
Opis:Medical implant-associated infections resulting from biofilm formation triggered by unspecific protein adsorption arethe prevailing cause of implant failure. However, implant surfaces rendered with multifunctional bioactive nanocoatings offer apromising alternative to prevent the initial attachment of bacteria and effectively interrupt biofilm formation. The need to researchand develop novel and stable bioactive nanocoatings for medical implants and a comprehensive understanding of their properties incontact with the complex biological environment are crucial. In this study, we developed an aqueous stable and crosslinker-freepolyelectrolyte−surfactant complex (PESC) composed of a renewable cationic polysaccharide, chitosan, a lysine-based anionicsurfactant (77KS), and an amphoteric antibiotic, amoxicillin, which is widely used to treat a number of infections caused by bacteria.We successfully introduced the PESC as bioactive functional nanolayers on the“model”and“real”polydimethylsiloxane (PDMS)surfaces under dynamic and ambient conditions. Besides their high stability and improved wettability, these uniformly depositednanolayers (thickness: 44−61 nm) with mixed charges exhibited strong repulsion toward three model blood proteins (serumalbumin,fibrinogen, andγ-globulin) and their competitive interactions in the mixture in real-time, as demonstrated using a quartzcrystal microbalance with dissipation (QCM-D). The functional nanolayers with a maximum negative zeta potential (ζ:−19 to−30mV at pH 7.4), water content (1628−1810 ng cm−2), and hydration (low viscosity and elastic shear modulus) correlated with themass, conformation, and interaction nature of proteins. In vitro antimicrobial activity testing under dynamic conditions showed thatthe charged nanolayers actively inhibited the growth of both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcusaureus) bacteria compared to unmodified PDMS. Given the ease of fabrication of multifunctional and charged biobased coatingswith simultaneous protein-repellent and antimicrobial activities, the limitations of individual approaches could be overcome leadingto a better and advanced design of various medical devices (e.g., catheters, prosthetics, and stents).
Ključne besede:silicone implants, protein-repellent, antimicrobial, chitosan, lysine, bioactive coatings, adsorption, QCM-D
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Poslano v recenzijo:29.01.2021
Datum sprejetja članka:04.05.2021
Datum objave:17.05.2021
Založnik:ACS Publications
Leto izida:2021
Št. strani:str. 23352–23368
Številčenje:Vol. 13, iss. 20
PID:20.500.12556/DKUM-88322 Novo okno
UDK:677.017:579
COBISS.SI-ID:63734787 Novo okno
DOI:10.1021/acsami.1c01993 Novo okno
ISSN pri članku:1944-8244
Datum objave v DKUM:15.04.2024
Število ogledov:266
Število prenosov:17
Metapodatki:XML DC-XML DC-RDF
Področja:Ostalo
:
AJDNIK, Urban, FRAS ZEMLJIČ, Lidija, PLOHL, Olivija, PÉREZ, Lourdes, TRČEK, Janja, BRAČIČ, Matej in MOHAN, Tamilselvan, 2021, Bioactive functional nanolayers of chitosan-lysine surfactant with single- and mixed-protein-repellent and antibiofilm properties for medical implants. ACS applied materials & interfaces [na spletu]. 2021. Vol. 13, no. 20. [Dostopano 6 april 2025]. DOI 10.1021/acsami.1c01993. Pridobljeno s: https://dk.um.si/IzpisGradiva.php?lang=slv&id=88322
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Gradivo je del revije

Naslov:ACS applied materials & interfaces
Skrajšan naslov:ACS appl. mater. interfaces
Založnik:American Chemical Society
ISSN:1944-8244
COBISS.SI-ID:14731286 Novo okno

Gradivo je financirano iz projekta

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P2-0118-2015
Naslov:Tekstilna kemija
Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:J4-1764-2019
Naslov:Razvoj multifunkcionalnih polisaharidnih kompozitnih nanodelcev za razkislinjenje, izboljšanje trdnosti in preprečevanje mikrobiološkega napada zgodovinskih artefaktov na osnovi celuloze

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Opis:
Ključne besede:silikonski vsadki, biomedicinski materiali, protimikrobnost, hitozan, bioaktivni premazi, adsorpcija


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