| | SLO | ENG | Piškotki in zasebnost

Večja pisava | Manjša pisava
Prva stran > Izpis gradiva

Izpis gradiva Pomoč

Naslov:Self-organization of enzyme-catalyzed reactions studied by the maximum entropy production principle
Avtorji:ID Dobovišek, Andrej (Avtor)
ID Vitas, Marko (Avtor)
ID Blaževič, Tina (Avtor)
ID Markovič, Rene (Avtor)
ID Marhl, Marko (Avtor)
ID Fajmut, Aleš (Avtor)
Datoteke:.pdf RAZ_Dobovisek_Andrej_2023.pdf (2,57 MB)
MD5: DCACFD4480BE2894159EFF2B0C3B8E19
 
URL https://www.mdpi.com/1422-0067/24/10/8734
 
Jezik:Angleški jezik
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FNM - Fakulteta za naravoslovje in matematiko
MF - Medicinska fakulteta
PEF - Pedagoška fakulteta
FZV - Fakulteta za zdravstvene vede
Opis:The self-organization of open reaction systems is closely related to specific mechanisms that allow the export of internally generated entropy from systems to their environment. According to the second law of thermodynamics, systems with effective entropy export to the environment are better internally organized. Therefore, they are in thermodynamic states with low entropy. In this context, we study how self-organization in enzymatic reactions depends on their kinetic reaction mechanisms. Enzymatic reactions in an open system are considered to operate in a non-equilibrium steady state, which is achieved by satisfying the principle of maximum entropy production (MEPP). The latter is a general theoretical framework for our theoretical analysis. Detailed theoretical studies and comparisons of the linear irreversible kinetic schemes of an enzyme reaction in two and three states are performed. In both cases, in the optimal and statistically most probable thermodynamic steady state, a diffusion-limited flux is predicted by MEPP. Several thermodynamic quantities and enzymatic kinetic parameters, such as the entropy production rate, the Shannon information entropy, reaction stability, sensitivity, and specificity constants, are predicted. Our results show that the optimal enzyme performance may strongly depend on the number of reaction steps when linear reaction mechanisms are considered. Simple reaction mechanisms with a smaller number of intermediate reaction steps could be better organized internally and could allow fast and stable catalysis. These could be features of the evolutionary mechanisms of highly specialized enzymes.
Ključne besede:enzymes, kinetic data analysis, steady state, self-organization, maximum entropy production
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Poslano v recenzijo:31.03.2023
Datum sprejetja članka:12.05.2023
Datum objave:13.05.2023
Leto izida:2023
Št. strani:21 str.
Številčenje:Vol. 24, iss. 10
PID:20.500.12556/DKUM-88180 Novo okno
UDK:536.75
COBISS.SI-ID:152729603 Novo okno
DOI:10.3390/ijms24108734 Novo okno
ISSN pri članku:1422-0067
Datum objave v DKUM:08.05.2024
Število ogledov:234
Število prenosov:11
Metapodatki:XML DC-XML DC-RDF
Področja:Ostalo
:
DOBOVIŠEK, Andrej, VITAS, Marko, BLAŽEVIČ, Tina, MARKOVIČ, Rene, MARHL, Marko in FAJMUT, Aleš, 2023, Self-organization of enzyme-catalyzed reactions studied by the maximum entropy production principle. International journal of molecular sciences [na spletu]. 2023. Vol. 24, no. 10. [Dostopano 9 april 2025]. DOI 10.3390/ijms24108734. Pridobljeno s: https://dk.um.si/IzpisGradiva.php?lang=slv&id=88180
Kopiraj citat
  
Skupna ocena:
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
Objavi na:Bookmark and Share


Iščem podobna dela...Prosim, počakajte...
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.

Gradivo je del revije

Naslov:International journal of molecular sciences
Skrajšan naslov:Int. j. mol. sci.
Založnik:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 Novo okno

Gradivo je financirano iz projekta

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P1-0055-2022
Naslov:Biofizika polimerov, membran, gelov, koloidov in celic
Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:J3-3077-2021
Naslov:Analiza kolektivne celične aktivnosti v normalnih in diabetičnih pankreatičnih otočkih s principi večplastnih mrež

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj
Logotipi partnerjev Univerza v Mariboru Univerza v Ljubljani Univerza na Primorskem Univerza v Novi Gorici