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Naslov:A co-culture model of the developing small intestine offers new insight in the early immunomodulation of enterocytes and macrophages by Lactobacillus spp. through STAT1 and NF-kB p65 translocation
Avtorji:ID Trapečar, Martin (Avtor)
ID Goropevšek, Aleš (Avtor)
ID Gorenjak, Mario (Avtor)
ID Gradišnik, Lidija (Avtor)
ID Rupnik, Marjan (Avtor)
Datoteke:.pdf PLoS_ONE_2014_Trapecar_et_al._A_Co-Culture_Model_of_the_Developing_Small_Intestine_Offers_New_Insight_in_the_Early_Immunomodulation_of_E.PDF (2,86 MB)
MD5: F53EB2983D397E8F292C7D208E876F5B
 
URL http://dx.plos.org/10.1371/journal.pone.0086297
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Opis:The early establishment of a complete microbiome has been shown to play an integral part in the development and maintenance of an intact intestine and its immune system, although much remains unknown about the specific mechanisms of immune modulation in newborns. In our study we show in a co-culture model of the undeveloped small intestine that members of Lactobacillus spp. influence STAT1 and NF-kB p65 nuclear translocation in both intestinal epithelial cells as well as underlying macrophages. Moreover, by using imaging flow cytometry we were able to monitor each individual cell and create a framework of the percentage of cells in which translocation occurred in challenged versus control cell populations. We also observed a significant difference in baseline translocation in intestinal cells when cultured alone versus those in a co-culture model, underpinning the importance of 3D models over monolayer set-ups in epithelial in vitro research. In conclusion, our work offers new insights into the potential routes by which the commensal microbiome primes the early immune system to fight pathogens, and shows how strain-specific these mechanisms really are.
Ključne besede:microbiome, Lactobacillus, immune system, pathogens
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Leto izida:2014
Št. strani:str. 1-8
Številčenje:Letn. 9, št. 1
PID:20.500.12556/DKUM-66266 Novo okno
ISSN:1932-6203
UDK:579.864
COBISS.SI-ID:512370232 Novo okno
DOI:10.1371/journal.pone.0086297 Novo okno
ISSN pri članku:1932-6203
NUK URN:URN:SI:UM:DK:AZJFRQRO
Datum objave v DKUM:19.06.2017
Število ogledov:1485
Število prenosov:372
Metapodatki:XML DC-XML DC-RDF
Področja:Ostalo
:
TRAPEČAR, Martin, GOROPEVŠEK, Aleš, GORENJAK, Mario, GRADIŠNIK, Lidija in RUPNIK, Marjan, 2014, A co-culture model of the developing small intestine offers new insight in the early immunomodulation of enterocytes and macrophages by Lactobacillus spp. through STAT1 and NF-kB p65 translocation. PloS one [na spletu]. 2014. Vol. 9, no. 1, p. 1–8. [Dostopano 4 april 2025]. DOI 10.1371/journal.pone.0086297. Pridobljeno s: https://dk.um.si/IzpisGradiva.php?lang=slv&id=66266
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Gradivo je del revije

Naslov:PloS one
Založnik:Public Library of Science
ISSN:1932-6203
COBISS.SI-ID:2005896 Novo okno

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:19.06.2017

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:mikrobiom, Lactobacillus, imunski sistem, patogeni


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